The placebo response in clinical trials: more questions than answers (Q37876002)

24 August 2017

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title

The placebo response in clinical trials: more questions than answers (English)

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24 August 2017

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Sibylle Klosterhalfen

series ordinal

object named as

Sibylle Klosterhalfen

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24 August 2017

Paul Enck

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24 August 2017

Björn Horing

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24 August 2017

Stephan Zipfel

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PMC publication ID

3130397

24 August 2017

language of work or name

English

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publication date

1 June 2011

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Philosophical Transactions of the Royal Society B

24 August 2017

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inferred from page(s)

published in

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24 August 2017

366

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24 August 2017

1572

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24 August 2017

1889-1895

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Therapy options in irritable bowel syndrome

24 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Effects of expectation on placebo-induced dopamine release in Parkinson disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Participant expectancies in double-blind randomized placebo-controlled trials: potential limitations to trial validity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Frequency and circumstances of placebo use in clinical practice--a systematic review of empirical studies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Inclusion of authorized deception in the informed consent process does not affect the magnitude of the placebo effect for experimentally induced pain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Biological, clinical, and ethical advances of placebo effects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Does inclusion of a placebo arm influence response to active antidepressant treatment in randomized controlled trials? Results from pooled and meta-analyses.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Practitioner empathy and the duration of the common cold

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Does study design influence outcome?. The effects of placebo control and treatment duration in antidepressant trials

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

The placebo response in functional dyspepsia--reanalysis of trial data

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Placebo response in randomized controlled trials of antidepressants for pediatric major depressive disorder

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

New insights into the placebo and nocebo responses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Placebo versus best-available-therapy control group in clinical trials for pharmacologic therapies: which is better?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Individual differences in reward responding explain placebo-induced expectations and effects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Predictors of the placebo response in functional dyspepsia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Deception in research on the placebo effect

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

The placebo effect in irritable bowel syndrome trials: a meta-analysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Overt versus covert treatment for pain, anxiety, and Parkinson's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Discrete coding of reward probability and uncertainty by dopamine neurons.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Intentional ignorance: a history of blind assessment and placebo controls in medicine.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Quantification of the placebo response in ulcerative colitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Estimating drug effects in the presence of placebo response: causal inference using growth mixture modeling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Hypertensive patients' willingness to participate in placebo-controlled trials: implications for recruitment efficiency

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Signal detection and placebo response in schizophrenia: parallels with depression.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

A prefrontal non-opioid mechanism in placebo analgesia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Declaration of Helsinki, 2008: implications for stakeholders in research

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Commercial features of placebo and therapeutic efficacy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

International ethical regulations on placebo-use in clinical trials: a comparative analysis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Worsening of depressive symptoms prior to randomization in clinical trials: a possible screen for placebo responders?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Unbalanced randomization influences placebo response: scientific versus ethical issues around the use of placebo in migraine trials.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

Superiority, equivalence or non-inferiority?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130397

The clinical significance of antidepressant treatment effects cannot be derived from placebo-verum response differences

5 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1098%2FRSTB.2010.0384

Double-blind versus deceptive administration of a placebo

21 January 2018

1 reference

12 December 2020

The powerful placebo: from ancient priest to modern physician

1 reference

12 December 2020

Separate mechanisms for placebo and opiate analgesia?

1 reference

12 December 2020

Are drug and placebo effects in depression additive?

1 reference

12 December 2020

Moderators of placebo response to antipsychotic treatment in patients with schizophrenia: a meta-regression

1 reference

12 December 2020

Suspended judgment. Memories of the British Streptomycin Trial in Tuberculosis. The first randomized clinical trial

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSTB.2010.0384

1 reference

24 August 2017

1 reference

PMC publication ID

3130397

24 August 2017

PubMed publication ID

21576146

1 reference

PMC publication ID

3130397