Testicular germ cell tumours: predisposition genes and the male germ cell niche. (Q37853838)

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25 January 2020

review article

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title

Testicular germ cell tumours: predisposition genes and the male germ cell niche (English)

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25 January 2020

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25 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21412254%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Elizabeth Rapley

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25 January 2020

language of work or name

English

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publication date

17 March 2011

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25 January 2020

published in

Nature Reviews Cancer

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25 January 2020

volume

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issue

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25 January 2020

page(s)

278-288

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Testicular germ-cell tumours in a broader perspective.

25 January 2020

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Guidance of primordial germ cell migration by the chemokine SDF-1.

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ERM is required for transcriptional control of the spermatogonial stem cell niche

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Plzf is required in adult male germ cells for stem cell self-renewal

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Essential role of Plzf in maintenance of spermatogonial stem cells

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A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis

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Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation

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Gene expression-based classification of nonseminomatous male germ cell tumors.

21 January 2018

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Gene expression profiling in seminoma and nonseminoma.

21 January 2018

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Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors

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Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours

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Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults.

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Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

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Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours.

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Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8.

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Pluripotency of spermatogonial stem cells from adult mouse testis

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The Y deletion gr/gr and susceptibility to testicular germ cell tumor

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Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer

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A genome-wide association study of testicular germ cell tumor

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Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer

21 January 2018

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Differential expression of the c-kit proto-oncogene in germ cell tumours.

21 January 2018

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KIT mutations are common in testicular seminomas

21 January 2018

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Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults

21 January 2018

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c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens

21 January 2018

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KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature.

21 January 2018

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Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

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Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice

21 January 2018

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Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase

21 January 2018

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Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis

21 January 2018

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Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors

21 January 2018

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N- and KRAS mutations in primary testicular germ cell tumors: incidence and possible biological implications

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Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.

21 January 2018

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Aberrant platelet-derived growth factor alpha-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis

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Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro

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Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.

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Mutations of BRAF and RAS are rare events in germ cell tumours.

21 January 2018

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Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.

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The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency

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Telomere dysfunction increases mutation rate and genomic instability

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Telomere dysfunction: a potential cancer predisposition factor.

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21 January 2018

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21 January 2018

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The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

21 January 2018

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MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity

21 January 2018

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Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease

21 January 2018

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Male infertility and androgen receptor gene mutations: clinical features and identification of seven novel mutations

21 January 2018

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Mutation screening and CAG repeat length analysis of the androgen receptor gene in Klinefelter's syndrome patients with and without spermatogenesis.

21 January 2018

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21 January 2018

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Association of long polyglycine tracts (GGN repeats) in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients

21 January 2018

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21 January 2018

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Environmental effects on hormonal regulation of testicular descent

21 January 2018

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Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

21 January 2018

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Genomic copy number and expression patterns in testicular germ cell tumours.

21 January 2018

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IGF2/H19 imprinting analysis of human germ cell tumors (GCTs) using the methylation-sensitive single-nucleotide primer extension method reflects the origin of GCTs in different stages of primordial germ cell development.

21 January 2018

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Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene

21 January 2018

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Stem cell factor as a novel diagnostic marker for early malignant germ cells.

21 January 2018

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Long-term followup results of 1 cycle of adjuvant bleomycin, etoposide and cisplatin chemotherapy for high risk clinical stage I nonseminomatous germ cell tumors of the testis

21 January 2018

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Curing metastatic cancer: lessons from testicular germ-cell tumours

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21 January 2018

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The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers

21 January 2018

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Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors

21 January 2018

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Loss of Oct-3/4 expression in embryonal carcinoma cells is associated with induction of cisplatin resistance.

21 January 2018

1 reference

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors

21 January 2018

1 reference

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer.

21 January 2018

1 reference

Low p21Waf1/Cip1 protein level sensitizes testicular germ cell tumor cells to Fas-mediated apoptosis.

21 January 2018

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Morphogens, morphostats, microarchitecture and malignancy

21 January 2018

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The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos

21 January 2018

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Age at surgery for undescended testis and risk of testicular cancer.

21 January 2018

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Age at Immigration and Duration of Stay in Relation to Risk for Testicular Cancer Among Finnish Immigrants in Sweden

21 January 2018

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Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism

21 January 2018

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Second Cancers Among 40 576 Testicular Cancer Patients: Focus on Long-term Survivors

21 January 2018

1 reference

i(12p): specific chromosomal marker in seminoma and malignant teratoma of the testis?

21 January 2018

1 reference

Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors

31 March 2020

1 reference

Possible carcinoma-in-situ of the testis

31 March 2020

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A fetus with Down syndrome and intratubular germ cell neoplasia

31 March 2020

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Carcinoma in situ of testicular tissue adjacent to malignant germ-cell tumors: a study of 105 cases

31 March 2020

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Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives

31 March 2020

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Cardiovascular morbidity in long-term survivors of metastatic testicular cancer.

31 March 2020

1 reference

Subfertility and the risk of testicular germ cell tumors (United States)

31 March 2020

1 reference

Somatic mutations of KIT in familial testicular germ cell tumours

31 March 2020

1 reference

Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones

31 March 2020

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Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

31 March 2020

1 reference

CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer

31 March 2020

1 reference

CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models

31 March 2020

1 reference

Short telomere length and breast cancer risk: a study in sister sets

31 March 2020

1 reference

Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism

31 March 2020

1 reference

The CAG repeat within the androgen receptor gene and its relationship to cryptorchidism

31 March 2020

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Genetics of Undescended Testis

31 March 2020

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Population-based investigation of familial undescended testis and its association with other urogenital anomalies

31 March 2020

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The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma

31 March 2020

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Molecular cytogenetic analysis of human spermatocytic seminomas

31 March 2020

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Medical Research Council prospective study of surveillance for stage I testicular teratoma. Medical Research Council Testicular Tumors Working Party

31 March 2020

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Short-course adjuvant chemotherapy in high-risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report

31 March 2020

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Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours

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MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

31 March 2020

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12 December 2020

Androgen receptor gene alterations are not associated with isolated cryptorchidism.

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12 December 2020

Quantification of human telomerase reverse transcriptase mRNA in testicular germ cell tumors by quantitative fluorescence real-time RT-PCR.

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12 December 2020

Expression of HER-2/neu in testicular tumors

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12 December 2020

Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt

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12 December 2020

Reduced androgen receptor gene expression with first exon CAG repeat expansion

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12 December 2020

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells

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12 December 2020

Expression of the CXCR4 and CCR7 chemokine receptors in human endometrial cancer

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12 December 2020

Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients.

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12 December 2020

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis

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12 December 2020

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors.

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12 December 2020

Reviews of chromosome studies in urological tumors. III. Cytogenetics and genes in testicular tumors

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12 December 2020

Germ-cell testicular cancer in offspring of Finnish immigrants to Sweden

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12 December 2020

A fetal testis with intratubular germ cell neoplasia (ITGCN)

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12 December 2020

New insights into male gametogenesis: what about the spermatogonial stem cell niche?

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12 December 2020

New insights into testicular germ cell tumorigenesis from gene expression profiling.

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12 December 2020

CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.

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12 December 2020

Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies

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12 December 2020

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

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12 December 2020

Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors

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12 December 2020

Coral growing on North Sea oil rigs

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12 December 2020

Identifiers

DOI

10.1038/NRC3021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21412254%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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