Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer (Q37859024)

24 August 2017

1 reference

title

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer (English)

1 reference

24 August 2017

Mark Mulvihill

1 reference

24 August 2017

Elizabeth Buck

1 reference

24 August 2017

language of work or name

English

0 references

publication date

30 March 2011

1 reference

Expert Opinion on Investigational Drugs

24 August 2017

published in

1 reference

24 August 2017

1 reference

24 August 2017

1 reference

24 August 2017

page(s)

605-621

1 reference

Structure and function of the type 1 insulin-like growth factor receptor.

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Structural biology of insulin and IGF1 receptors: implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin receptor structure and its implications for the IGF-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The three dimensional structure of the type I insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Role of insulin-like growth factors in embryonic and postnatal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The IGF-I signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The insulin-like growth factor system and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin regulation of the Ras activation/inactivation cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Relaxation of imprinted genes in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor binding proteins and their role in controlling IGF actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Overexpression of Insulin Receptors in Fibroblast and Ovary Cells Induces a Ligand-Mediated Transformed Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

21 January 2018

Insulin and colon cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor physiology and neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

A prospective study of plasma C-peptide and colorectal cancer risk in men

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Targeting insulin and insulin-like growth factor signalling in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor-I receptor signaling blockade combined with radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Insulin can modulate MCF-7 cell response to paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The IGF axis in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Linkage of Rapid Estrogen Action to MAPK Activation by ER -Shc Association and Shc Pathway Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Crosstalk between the insulin-like growth factors and estrogens in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Modulation of the proliferative response of breast cancer cells to growth factors by oestrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The growth hormone-deficient Spontaneous Dwarf rat is resistant to chemically induced mammary carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Structural and functional studies of insulin receptors in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Elevated insulin receptor content in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

17beta-Estradiol transcriptionally represses human insulin receptor gene expression causing cellular insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Interaction of IGF signaling and the androgen receptor in prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Figitumumab (CP-751,871) for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

IGF-1R targeted treatment of sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Molecular Analysis of Non–Small Cell Lung Cancer Identifies Subsets with Different Sensitivity to Insulin-like Growth Factor I Receptor Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.558501

10.1517/13543784.2011.558501

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference