Mechanism of cytotoxicity of paraquat (Q37856960)

24 August 2017

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title

Mechanism of cytotoxicity of paraquat (English)

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24 August 2017

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1 reference

24 August 2017

Tetsuhito Fukushima

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24 August 2017

Heejin Lim

series ordinal

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24 August 2017

Masaki Moriyama

series ordinal

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24 August 2017

1 July 2002

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Environmental Health and Preventive Medicine

24 August 2017

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24 August 2017

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24 August 2017

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24 August 2017

89-94

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Chemistry and biochemistry of oxidative stress in neurodegenerative disease

24 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

The mitochondrial theory of aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Hyperoxia inhibits oxidant-induced apoptosis in lung epithelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

A mechanism of paraquat toxicity involving nitric oxide synthase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Nitric oxide as a mediator of oxidant lung injury due to paraquat

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Stimulatory effect of FMN and methyl viologen on cytochrome P-450 dependent reduction of tertiary amine N-oxide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

The role of nitric oxide in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Apoptosis in human lung epithelial cells: triggering by paraquat and modulation by antioxidants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Paraquat induced pulmonary fibrosis in three survivors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Evidence for hydroxyl free radical formation during paraquat but not for nifurtimox liver microsomal biotransformation. A dimethyl-sulfoxide scavenging study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Paraquat-induced phosphatidylserine oxidation and apoptosis are independent of activation of PLA2.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Paraquat Inhibits the Processing of Human Manganese-Dependent Superoxide Dismutase by SF-9 Insect Cell Mitochondria

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Mechanism of cytotoxicity of paraquat. II. Organ specificity of paraquat-stimulated lipid peroxidation in the inner membrane of mitochondria

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Mechanism of cytotoxicity of paraquat. I. NADH oxidation and paraquat radical formation via complex I.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Alteration of inner-membrane components and damage to electron-transfer activities of bovine heart submitochondrial particles induced by NADPH-dependent lipid peroxidation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Effects of paraquat administration on longevity, oxygen consumption, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, inorganic peroxides and glutathione in the adult housefly.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Evidence for lipid peroxidation in man following paraquat ingestion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), cyperquat (MPP+) and paraquat on isolated mitochondria from rat striatum, cortex and liver

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Protein damage and degradation by oxygen radicals. II. Modification of amino acids

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

The role of respiratory chain in paraquat toxicity in yeast.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Overproduction of human Mn-superoxide dismutase modulates paraquat-mediated toxicity in mammalian cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

[Observations of the fibrosing process in paraquat lung injury by chest X-ray and CT]

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Dissociation of microsomal oxygen reduction and lipid peroxidation with the electron acceptors, paraquat and menadione

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Role of heat shock protein 60 (HSP60) on paraquat intoxication

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

NMDA receptor activation: critical role in oxidant tissue injury

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Effects of paraquat on mitochondrial electron transport system and catecholamine contents in rat brain.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Oxidative damage to mitochondria is mediated by the Ca2+-dependent inner-membrane permeability transition

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Niacin Reduces Paraquat Toxicity in Rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Reduction of paraquat toxicity by superoxide dismutase

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2723489

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-Methylcoumarins mediated by the formation of a stable ADP-Fe-Inhibitor

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1265%2FEHPM.2002.89

Inhibitory effect of nicotinamide to paraquat toxicity and the reaction site on complex I

21 January 2018

1 reference

12 December 2020

Influence of lipid peroxidation on beta-adrenoceptors

1 reference

12 December 2020

Mechanism of cytotoxicity of paraquat. III. The effects of acute paraquat exposure on the electron transport system in rat mitochondria

1 reference

12 December 2020

Nitric oxide inhalation for paraquat-induced lung injury

1 reference

12 December 2020

Relevance of NADPH depletion and mixed disulphide formation in rat lung to the mechanism of cell damage following paraquat administration

1 reference

12 December 2020

Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells

1 reference

12 December 2020

Mitochondria catalyze the reduction of NAD by reduced methylviologen

1 reference

12 December 2020

Induced mono-(ADP)-ribosylation of rat liver cytosolic proteins by lipid peroxidant agents

1 reference

12 December 2020

Cytotoxic effects of paraquat and inhibition of them by vitamin E

1 reference

12 December 2020

Correlation between lipid peroxidation and morphological manifestation of paraquat-induced lung injury in rats

1 reference

12 December 2020

Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure

1 reference

12 December 2020

Mitochondrial bioenergetics is affected by the herbicide paraquat

1 reference

12 December 2020

Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity

1 reference

12 December 2020

A Dual Effect of 1-Methyl-4-phenylpyridinium (MPP+)-Analogs on the Respiratory Chain of Bovine Heart Mitochondria

1 reference

12 December 2020

Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst. Effect of NADPH depletion by paraquat

1 reference

12 December 2020

Paraquat causes S-phase arrest of rat liver and lung cells in vivo

1 reference

12 December 2020

The effect of paraquat lung on mononuclear cells

1 reference

12 December 2020

Mitochondrial NADH–Quinone Oxidoreductase of the Outer Membrane Is Responsible for Paraquat Cytotoxicity in Rat Livers

1 reference

12 December 2020

Paraquat induces actin assembly in depolymerizing conditions

1 reference

12 December 2020

Free malondialdehyde levels in the urine of rats intoxicated with paraquat

1 reference

12 December 2020

Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase-1 in patients with paraquat poisoning

1 reference

12 December 2020

Radical formation site of cerebral complex I and Parkinson's disease

1 reference

12 December 2020

Lipid peroxidation by bovine heart submitochondrial particles stimulated by 1,1'-dimethyl-4,4'-bipyridylium dichloride (paraquat)

1 reference

12 December 2020

Comparison of one-electron reduction activity against the bipyridylium herbicides, paraquat and diquat, in microsomal and mitochondrial fractions of liver, lung and kidney (in vitro)

1 reference

12 December 2020

The cytotoxic effect of paraquat to isolated renal proximal tubular segments from rabbits

1 reference

12 December 2020

Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts

1 reference

12 December 2020

Identifiers

DOI

10.1265/EHPM.2002.89

1 reference

Dimensions Publication ID

24 August 2017

0 references

1 reference

24 August 2017

PubMed publication ID

21432289

1 reference