Screening Technologies for Ion Channel Drug Discovery (Q37855923)

24 August 2017

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title

Screening technologies for ion channel drug discovery (English)

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24 August 2017

Screening Technologies for Ion Channel Drug Discovery (English)

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28 November 2024

0 references

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Georg C Terstappen

1 reference

24 August 2017

Renza Roncarati

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24 August 2017

John Dunlop

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24 August 2017

Ravikumar Peri

series ordinal

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24 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21426199

28 November 2024

publication date

1 May 2010

1 reference

24 August 2017

May 2010

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21426199

full work available at URL

28 November 2024

https://www.tandfonline.com/doi/pdf/10.4155/fmc.10.180

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Future Medicinal Chemistry

28 November 2024

published in

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24 August 2017

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24 August 2017

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24 August 2017

page(s)

715-730

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The Sequence of the Human Genome

24 August 2017

cites work

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Membrane defects in paramyotonia congenita with and without myotonia in a warm environment.

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Mechanisms underlying epileptiform burst discharge

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

21 January 2018

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From molecule to malady

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Drugs, their targets and the nature and number of drug targets

21 January 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

21 January 2018

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Probing membrane potential with nonlinear optics

21 January 2018

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Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells

21 January 2018

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Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells

21 January 2018

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ATP-sensitive K+ channel opener acts as a potent Cl- channel inhibitor in vascular smooth muscle cells

21 January 2018

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Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition.

21 January 2018

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Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells

21 January 2018

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The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3.

21 January 2018

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Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes

21 January 2018

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A novel high-throughput screening assay for HCN channel blocker using membrane potential-sensitive dye and FLIPR.

21 January 2018

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State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents

21 January 2018

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Use of FLIPR membrane potential dyes for validation of high-throughput screening with the FLIPR and microARCS technologies: identification of ion channel modulators acting on the GABA(A) receptor

21 January 2018

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Identification of novel Kv1.3 blockers using a fluorescent cell-based ion channel assay.

21 January 2018

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Voltage sensing by fluorescence resonance energy transfer in single cells

21 January 2018

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Improved indicators of cell membrane potential that use fluorescence resonance energy transfer

21 January 2018

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Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

21 January 2018

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A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

21 January 2018

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Miniaturization and HTS of a FRET-based membrane potential assay for K(ir) channel inhibitors

21 January 2018

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The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels

21 January 2018

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Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development

21 January 2018

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Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

21 January 2018

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Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.

21 January 2018

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Cellular HTS assays for pharmacological characterization of Na(V)1.7 modulators

21 January 2018

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Development and validation of HTS flux assay for endogenously expressed chloride channels in a CHO-K1 cell line

21 January 2018

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Quantitative fluorescence measurement of chloride transport mechanisms in phospholipid vesicles.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.180

Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators

21 January 2018

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A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors.

21 January 2018

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A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

21 January 2018

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A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

21 January 2018

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Ionworks HT: a new high-throughput electrophysiology measurement platform.

21 January 2018

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Population patch clamp improves data consistency and success rates in the measurement of ionic currents

21 January 2018

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High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Impact of novel screening technologies on ion channel drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen

21 January 2018

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Novel 384-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels.

21 January 2018

1 reference

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Validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel enhancers using IonWorks HT.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches

21 January 2018

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Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay

21 January 2018

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Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks.

21 January 2018

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Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms

21 January 2018

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An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.180

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

21 January 2018

1 reference

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21 January 2018

Ion channel screening

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Use of planar array electrophysiology for the development of robust ion channel cell lines

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.180

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

21 January 2018

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Automated voltage-clamp technique.

21 January 2018

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Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.180

QPatch: the missing link between HTS and ion channel drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated ion channel screening: patch clamping made easy

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.180

Ion channel drug discovery and research: the automated Nano-Patch-Clamp technology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

High quality ion channel analysis on a chip with the NPC technology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Optimization of Ca(v)1.2 screening with an automated planar patch clamp platform

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

An automated electrophysiology serum shift assay for K(V) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated patch clamping using the QPatch.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Automated patch-clamp technique: increased throughput in functional characterization and in pharmacological screening of small-conductance Ca2+ release-activated Ca2+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

In vitro screening strategies for nicotinic receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.180

Episodic ataxias as channelopathies

21 January 2018

1 reference

High-Throughput Screening for Ion Channel Modulators

28 November 2024

1 reference

Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine.

28 November 2024

1 reference

Effects of ryanodine and caffeine on contractility, membrane voltage, and calcium exchange in cultured heart cells

28 November 2024

1 reference

Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay

28 November 2024

1 reference

Assay technologies for screening ion channel targets.

28 November 2024

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High throughput ion-channel pharmacology: planar-array-based voltage clamp

28 November 2024

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Differential inhibition of inducible T cell cytokine secretion by potent iron chelators.

28 November 2024

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Development and validation of a secondary screening assay for TRPM8 antagonists using QPatch HT.

28 November 2024

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28 November 2024

Identifiers

DOI

10.4155/FMC.10.180

1 reference

24 August 2017

1 reference