Myelodysplastic syndromes: an update on molecular pathology. (Q37800283)

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scientific article published on October 2010

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English	Myelodysplastic syndromes: an update on molecular pathology.	scientific article published on October 2010

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scholarly article

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PubMed publication ID

20947479

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15 February 2020

title

Myelodysplastic syndromes: an update on molecular pathology (English)

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Europe PubMed Central

PubMed publication ID

20947479

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15 February 2020

main subject

pathology

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author

Mar Tormo

series ordinal

1

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Europe PubMed Central

PubMed publication ID

20947479

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15 February 2020

author name string

Isabel Marugán

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2

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PubMed publication ID

20947479

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15 February 2020

Marisa Calabuig

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3

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PubMed publication ID

20947479

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15 February 2020

publication date

1 October 2010

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PubMed publication ID

20947479

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15 February 2020

published in

Clinical and Translational Oncology

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Europe PubMed Central

PubMed publication ID

20947479

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15 February 2020

volume

12

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Europe PubMed Central

PubMed publication ID

20947479

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15 February 2020

issue

10

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Europe PubMed Central

PubMed publication ID

20947479

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15 February 2020

page(s)

652-661

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PubMed publication ID

20947479

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15 February 2020

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Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion

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Control of apoptosis by Rel/NF-kappaB transcription factors

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Apoptosis in patients with myelodysplastic syndromes: differential involvement of marrow cells in 'good' versus 'poor' prognosis patients and correlation with apoptosis-related genes

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Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes

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Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation

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Advancements in the molecular pathogenesis of myelodysplastic syndrome.

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Chromosomal deletions in the myelodysplastic syndrome

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CpG island methylator phenotype in colorectal cancer

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12 December 2020

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Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders

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Synthesis and incorporation of human ribosomal protein S14 into functional ribosomes in human-Chinese hamster cell hybrids containing human chromosome 5: human RPS14 gene is the structural gene for ribosomal protein S14.

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Fas (CD95) receptor and Fas-ligand expression in bone marrow cells from patients with myelodysplastic syndrome

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Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome

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12 December 2020

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Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS).

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12 December 2020

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Role of nucleophosmin in embryonic development and tumorigenesis

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12 December 2020

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The epigenomics of cancer

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

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Gene expression profiling of CD34+cells in patients with the 5q− syndrome

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12 December 2020

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The role of the immune system in myelodysplasia: implications for therapy

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12 December 2020

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Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: relationships and distinctions-a review

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PubMed

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12 December 2020

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Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

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The cytogenetics of myelodysplastic syndromes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk factors of myelodysplastic syndromes: a case-control study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of FLIPLong and FLIPShort in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

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Mitochondria and apoptosis

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12 December 2020

based on heuristic

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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

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12 December 2020

based on heuristic

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Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical importance of interphase cytogenetics detecting occult chromosome lesions in myelodysplastic syndromes with normal karyotype

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12 December 2020

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Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996).

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Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

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PubMed

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12 December 2020

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DNA methylation in health and disease

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PubMed

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12 December 2020

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Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes

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PubMed

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12 December 2020

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NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

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Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

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inferred from PubMed ID database lookup

RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'Low-risk' myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- versus anti-apoptotic bcl-2-related proteins

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelodysplastic syndromes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deciphering the transcriptional histone acetylation code for a human gene

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haploinsufficiency of Apc leads to ineffective hematopoiesis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytogenetic studies of a series of 43 consecutive secondary myelodysplastic syndromes/acute myeloid leukemias: conventional cytogenetics, FISH, and multiplex FISH

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The most unkindest cut of all: on the multiple roles of mammalian caspases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial myelodysplasia and acute myeloid leukaemia--a review

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biochemistry of apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

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Incidence, characterization and prognostic significance of chromosomal abnormalities in 640 patients with primary myelodysplastic syndromes. Grupo Cooperativo Español de Citogenética Hematológica

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12 December 2020

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Code of silence

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS)

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Van-den Berghe's 5q- syndrome in 2008.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4(+) subset and oligoclonal in the CD8(+) subset

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor-induced gene expression in human marrow stroma: clues to the pathophysiology of MDS?

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International scoring system for evaluating prognosis in myelodysplastic syndromes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced expression of FLIP SHORT in bone marrow of low risk myelodysplastic syndrome.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosomopathies: human disorders of ribosome dysfunction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrow cells isolated from patients with refractory anemia with ringed sideroblasts

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer: hay in a haystack

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APC, signal transduction and genetic instability in colorectal cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20947479

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12 December 2020

based on heuristic

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Identifiers

DOI

10.1007/S12094-010-0574-9

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20947479

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20947479%20AND%20SRC:MED&resulttype=core&format=json

retrieved

15 February 2020

Fatcat ID

release_osseuk5uzfhwre4by6mpkoknuy

1 reference

stated in

Fatcat

reference URL

https://api.fatcat.wiki/v0/release/osseuk5uzfhwre4by6mpkoknuy

retrieved

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

20947479

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20947479

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20947479%20AND%20SRC:MED&resulttype=core&format=json

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15 February 2020

 

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