Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts? (Q37809299)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Paul A Johnston

1 reference

23 August 2017

11 November 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Chemical Biology

16 January 2020

published in

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16 January 2020

volume

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16 January 2020

issue

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16 January 2020

page(s)

174-182

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Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

16 January 2020

cites work

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6 September 2017

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

6 September 2017

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Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

6 September 2017

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Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

6 September 2017

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Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

6 September 2017

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6 September 2017

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Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

6 September 2017

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Reactive species: a cell damaging rout assisting to chemical carcinogens

6 September 2017

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Characterization of chemical libraries for luciferase inhibitory activity

6 September 2017

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Fluorescence spectroscopic profiling of compound libraries

6 September 2017

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Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

6 September 2017

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High-throughput screening assays for the identification of chemical probes

6 September 2017

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Cell signaling. H2O2, a necessary evil for cell signaling

6 September 2017

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Protein-tyrosine phosphatases and cancer

6 September 2017

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Statistical practice in high-throughput screening data analysis

6 September 2017

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Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

6 September 2017

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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

6 September 2017

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Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays

6 September 2017

1 reference

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Redox cycling of beta-lapachone and structural analogues in microsomal and cytosol liver preparations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040250

Improved statistical methods for hit selection in high-throughput screening

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040250

Cellular regulation by hydrogen peroxide

6 September 2017

1 reference

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Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

6 September 2017

1 reference

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Reversible inactivation of the tumor suppressor PTEN by H2O2

6 September 2017

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Cellular platforms for HTS: three case studies

6 September 2017

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Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation

6 September 2017

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6 September 2017

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The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide

6 September 2017

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Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways

23 June 2018

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23 June 2018

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A fluorescence-based coupling reaction for monitoring the activity of recombinant human NAD synthetase

23 June 2018

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Redox regulation of Cdc25B by cell-active quinolinediones

1 September 2018

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Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition

1 September 2018

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Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21075044

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Redox regulation of MAP kinase phosphatase 3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21075044

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A simple assay for detection of small-molecule redox activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21075044

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2010.10.022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

21075044

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21075044%20AND%20SRC:MED&resulttype=core&format=json