Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA (Q37798546)

23 August 2017

title

Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA (English)

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

28 July 2024

0 references

1 reference

0 references

William Lewis

1 reference

23 August 2017

Christopher A. Koczor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929279

28 July 2024

language of work or name

English

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publication date

7 October 2010

1 reference

full work available at URL

23 August 2017

http://www.informapharmascience.com/doi/abs/10.1517/17425255.2010.526602

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929279

http://www.tandfonline.com/doi/pdf/10.1517/17425255.2010.526602

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Expert Opinion on Drug Metabolism & Toxicology

28 July 2024

published in

1 reference

23 August 2017

1 reference

23 August 2017

1 reference

23 August 2017

page(s)

1493-1504

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Contraception choice for HIV positive women

23 August 2017

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Mitochondrial myopathy caused by long-term zidovudine therapy

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Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

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Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

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Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

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AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

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Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice

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21 January 2018

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Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging.

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Large hepatic mitochondrial DNA deletions associated with L-lactic acidosis and highly active antiretroviral therapy

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Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors

21 January 2018

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Multiple mitochondrial DNA deletions and lactic acidosis in an HIV-infected patient under antiretroviral therapy

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Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs

21 January 2018

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Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity

21 January 2018

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Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation

21 January 2018

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Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

21 January 2018

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Transgenic cardiac-targeted overexpression of human thymidylate kinase

21 January 2018

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Antiretroviral therapy: strategies beyond single-agent reverse transcriptase inhibition

21 January 2018

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

21 January 2018

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Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

21 January 2018

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Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine

21 January 2018

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Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs

21 January 2018

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Mechanism of active renal tubular efflux of tenofovir

21 January 2018

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Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion.

21 January 2018

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Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction

21 January 2018

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Human immunodeficiency virus type 1 infection and myopathy: clinical relevance of zidovudine therapy

21 January 2018

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Muscle disease, HIV and zidovudine: the spectrum of muscle disease in HIV-infected individuals treated with zidovudine

21 January 2018

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Lamivudine-induced muscle mitochondrial toxicity.

21 January 2018

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Mitochondrial toxicity and HIV therapy

21 January 2018

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21 January 2018

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21 January 2018

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Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

21 January 2018

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Absence of mitochondrial toxicity in hearts of transgenic mice treated with abacavir

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Peripheral neuropathy and antiretroviral drugs

21 January 2018

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Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2'3'-dideoxycytidine (ddC).

21 January 2018

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21 January 2018

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21 January 2018

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2',3'-didehydro-3'-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial

21 January 2018

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Exacerbation of peripheral neuropathy by lamivudine

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2',3'-dideoxycytidine (ddC).

21 January 2018

1 reference

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21 January 2018

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HIV pharmacogenetics in clinical practice: recent achievements and future challenges

21 January 2018

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Iron metabolism and mitochondrial abnormalities in Friedreich ataxia

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Cardiovascular risk and body-fat abnormalities in HIV-infected adults

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Lipodystrophy in HIV 1-infected patients: lessons for obesity research

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Does antiretroviral therapy increase or decrease the risk of cardiovascular disease?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

21 January 2018

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HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

21 January 2018

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Influence of coinfection with hepatitis C virus on morbidity and mortality due to human immunodeficiency virus infection in the era of highly active antiretroviral therapy

21 January 2018

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Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action

21 January 2018

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Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA).

21 January 2018

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Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions

21 January 2018

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The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

21 January 2018

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Aging and HIV infection: a comparison between older HIV-infected persons and the general population

21 January 2018

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Stavudine versus zidovudine and the development of lipodystrophy

21 January 2018

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Lamivudine for the treatment of HIV.

21 January 2018

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In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.526602

Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis

21 January 2018

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https://api.crossref.org/works/10.1517/17425255.2010.526602

Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine

28 July 2024

1 reference

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28 July 2024

Molecular Pharmacology

625

Chen CH

1991

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Serum levels and catabolism of 3'-azido-3'-deoxythymidine in vivo measured using a specific radioimmunoassay

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT)

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase

28 July 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2010.526602

Hepatomegaly with severe steatosis in HIV-seropositive patients

28 July 2024

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https://api.crossref.org/works/10.1517/17425255.2010.526602

Oxidative stress causes heart failure with impaired mitochondrial respiration

28 July 2024

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https://api.crossref.org/works/10.1517/17425255.2010.526602

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

28 July 2024

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28 July 2024

Identifiers

1 reference

23 August 2017

1 reference