TRPM2 channel properties, functions and therapeutic potentials (Q37776522)

23 August 2017

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title

TRPM2 channel properties, functions and therapeutic potentials (English)

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23 August 2017

Lin-Hua Jiang

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David J Beech

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Wei Yang

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23 August 2017

Jie Zou

series ordinal

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23 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Opinion on Therapeutic Targets

23 August 2017

published in

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23 August 2017

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23 August 2017

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23 August 2017

page(s)

973-988

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Oxidative stress in Alzheimer's disease

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Calcium signaling and oxidant stress in the vasculature

21 January 2018

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Free radicals in the physiological control of cell function

21 January 2018

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Reactive oxygen species in the vasculature: molecular and cellular mechanisms

21 January 2018

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Reactive oxygen species and the modulation of stroke.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Oxidative stress: apoptosis in neuronal injury

21 January 2018

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Redox signaling in hypertension

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

NF-kappaB activation by reactive oxygen species: fifteen years later

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Role of microglial redox balance in modulation of neuroinflammation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Calcium hypothesis of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

The versatility and universality of calcium signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

From worm to man: three subfamilies of TRP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

The TRP channels, a remarkably functional family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRP channels as cellular sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Sensing with TRP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

21 January 2018

TRP proteins and cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

21 January 2018

TRP channels and pain

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Transient receptor potential channels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Neuronal TRP channels: thermometers, pathfinders and life-savers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Mechanosensitive TRP channels in cardiovascular pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Transient receptor potential channels: targeting pain at the source

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

The role of transient receptor potential channels in kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Transient receptor potential cation channels in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

The TRPM ion channel subfamily: molecular, biophysical and functional features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Immunocyte Ca2+ influx system mediated by LTRPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 Ca2+ permeable cation channels: from gene to biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Regulation of TRPM2 by extra- and intracellular calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Permeation and selectivity of TRP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Subunit interaction in channel assembly and functional regulation of transient receptor potential melastatin (TRPM) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Trafficking and assembly of the cold-sensitive TRPM8 channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Coiled coils direct assembly of a cold-activated TRP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Evolutionary determinants of divergent calcium selectivity of TRPM channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Tissue distribution profiles of the human TRPM cation channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat beta-cell line RIN-5F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Sustained depolarization and ADP-ribose activate a common ionic current in rat peritoneal macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Activation of T cell calcium influx by the second messenger ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Identification of novel sense and antisense transcription at the TRPM2 locus in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Expansion of the eukaryotic proteome by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Regulation of calcium signalling by adenine-based second messengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Flufenamic acid is a pH-dependent antagonist of TRPM2 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Pharmacology of transient receptor potential melastatin channels in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Calmodulin as an ion channel subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Reduced glutathione inhibits beta-NAD+-activated non-selective cation currents in the CRI-G1 rat insulin-secreting cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Characterization of a nicotinamide-adenine dinucleotide-dependent cation channel in the CRI-G1 rat insulinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRP channels in endothelial function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 channel regulates endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Role of Ca2+ signaling in the regulation of endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Multiple cascade effects of oxidative stress on astroglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Transurethral resection of the prostate with a bipolar tissue management system compared to conventional monopolar resectoscope: one-year outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Role of an N-terminal splice segment in the activation of the cation channel TRPM2 by ADP-ribose and hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Generation of functional ion-channel tools by E3 targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

TRPC channel activation by extracellular thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Production of a specific extracellular inhibitor of TRPM3 channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

Another TRP to Endothelial Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.510135

10.1517/14728222.2010.510135

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference