Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. (Q37763842)

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5 February 2020

review article

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title

Cartilage tumours and bone development: molecular pathology and possible therapeutic targets (English)

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5 February 2020

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5 February 2020

Pancras C.W. Hogendoorn

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5 February 2020

Jay S Wunder

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5 February 2020

Benjamin A Alman

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5 February 2020

language of work or name

English

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publication date

10 June 2010

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5 February 2020

published in

Nature Reviews Cancer

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5 February 2020

volume

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5 February 2020

issue

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5 February 2020

page(s)

481-488

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Developmental regulation of the growth plate

5 February 2020

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Molecular analysis of the INK4A/INK4A-ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for tumour progression

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Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors

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Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma

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Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group

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Array-comparative genomic hybridization of central chondrosarcoma: identification of ribosomal protein S6 and cyclin-dependent kinase 4 as candidate target genes for genomic aberrations.

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Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro

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Chromosome 9 alterations and trisomy 22 in central chondrosarcoma: a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes

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Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues

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Alterations in the regulatory pathway involving p16, pRb and cdk4 in human chondrosarcoma.

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Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

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PTEN mutation is rare in chondrosarcoma.

31 March 2020

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Hypoxia induces HIF-1Œ± and VEGF expression in chondrosarcoma cells and chondrocytes

31 March 2020

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Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1beta.

31 March 2020

1 reference

Angiogenic Cytokines in Cartilage Tumors

31 March 2020

2 references

31 March 2020

12 December 2020

Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours

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Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma

31 March 2020

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Intrinsic radiation resistance in human chondrosarcoma cells

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Correlation of hypoxic signalling to histological grade and outcome in cartilage tumours

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cDNA expression profiling of chondrosarcomas: Ollier disease resembles solitary tumours and alteration in genes coding for components of energy metabolism occurs with increasing grade.

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31 March 2020

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Identifiers

DOI

10.1038/NRC2869

1 reference

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5 February 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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