Current standards in the treatment of metastatic breast cancer with focus on Lapatinib: a review by a Central European Consensus Panel (Q37765198)

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scientific article published on 15 June 2010

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English	Current standards in the treatment of metastatic breast cancer with focus on Lapatinib: a review by a Central European Consensus Panel	scientific article published on 15 June 2010

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title

Current standards in the treatment of metastatic breast cancer with focus on Lapatinib: a review by a Central European Consensus Panel (English)

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20549373

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main subject

metastatic breast cancer

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author

Jacek Jassem

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Jacek Jassem

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Europe PubMed Central

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Renata Duchnowska

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Renata Duchnowska

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20549373

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Valentina Tzekova

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Valentina Tzekova

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20549373

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Alvydas Cesas

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Alvydas Cesas

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Gunta Purkalne

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Gunta Purkalne

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Constanta Timcheva

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Constanta Timcheva

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Florin Bacanu

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Florin Bacanu

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Alexandru Eniu

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Alexandru Eniu

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author name string

Guenther G Steger

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Jitka Abrahámová

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20549373

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Stephen Brincat

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Arija Brize

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Tanja Cufer

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Magdolna Dank

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Zsuzsanna Kahán

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Erika Matos

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Peeter Padrik

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Signe Plāte

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Helis Pokker

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Rostislav Vyzula

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Christoph C Zielinski

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publication date

15 June 2010

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20549373

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22 August 2017

published in

Vienna Clinical Weekly

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20549373

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volume

122

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issue

11-12

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page(s)

368-379

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Two cases of rapid onset Parkinson's syndrome following toxic ingestion of ethylene glycol and methanol

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Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

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Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials

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Adjuvant/neoadjuvant trastuzumab therapy in women with HER-2/neu-overexpressing breast cancer: a systematic review

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Lapatinib: a tyrosine kinase inhibitor with a clinical role in breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer.

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PubMed

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Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma

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Cardiac dysfunction in the trastuzumab clinical trials experience

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Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Pooled analysis of diarrhea events in patients with cancer treated with lapatinib

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Lapatinib moves forward in inflammatory and early HER2-positive breast cancer trials

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses

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https://pubmed.ncbi.nlm.nih.gov/20549373

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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A review of lapatinib ditosylate in the treatment of refractory or advanced breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Her2 cross talk and therapeutic resistance in breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Facts and controversies in systemic treatment of metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Regulation and targets of receptor tyrosine kinases

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Is breast cancer survival improving?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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inferred from PubMed ID database lookup

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Untangling the ErbB signalling network

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12 December 2020

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Her-2 targeted therapy: beyond breast cancer and trastuzumab

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Taxanes in breast cancer: an update

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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The impact of new chemotherapeutic and hormone agents on survival in a population-based cohort of women with metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Chemotherapy alone versus endocrine therapy alone for metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Estimates of the cancer incidence and mortality in Europe in 2006.

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PubMed

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12 December 2020

based on heuristic

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Cardiovascular toxicity with cancer chemotherapy.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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CNS metastases in breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Second consensus on medical treatment of metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: impact on patient management

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Cytotoxic and hormonal treatment for metastatic breast cancer: a systematic review of published randomized trials involving 31,510 women

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single agent versus combination chemotherapy for metastatic breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted therapies for the treatment of breast cancer in the post-trastuzumab era.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer with synchronous metastases: trends in survival during a 14-year period

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical efficacy of taxane-trastuzumab combination regimens for HER-2-positive metastatic breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

based on heuristic

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Trastuzumab-induced cardiomyopathy.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20549373

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12 December 2020

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Identifiers

DOI

10.1007/S00508-010-1373-6

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20549373

retrieved

22 August 2017

PubMed publication ID

20549373

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20549373

retrieved

22 August 2017

 

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