Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis. (Q37730801)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

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17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Arna Katewa

1 reference

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17 March 2020

Yugang Wang

1 reference

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17 March 2020

Tao Huang

1 reference

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17 March 2020

Eric Suto

1 reference

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17 March 2020

Nandhini Ramamoorthi

1 reference

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17 March 2020

Cary D Austin

1 reference

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17 March 2020

Meire Bremer

1 reference

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17 March 2020

Jacob Zhi Chen

1 reference

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17 March 2020

Kevin S Currie

1 reference

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17 March 2020

Peter Blomgren

1 reference

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17 March 2020

Jason DeVoss

1 reference

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17 March 2020

Julie A DiPaolo

1 reference

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17 March 2020

Jonathan Hau

1 reference

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17 March 2020

Adam Johnson

1 reference

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17 March 2020

Justin Lesch

1 reference

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17 March 2020

Laura E DeForge

1 reference

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17 March 2020

Zhonghua Lin

1 reference

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17 March 2020

Marya Liimatta

1 reference

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17 March 2020

Joseph W Lubach

1 reference

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17 March 2020

Sami McVay

1 reference

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17 March 2020

Allen Nguyen

1 reference

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17 March 2020

Chungkee Poon

1 reference

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17 March 2020

Jianyong Wang

1 reference

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17 March 2020

Lichuan Liu

1 reference

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17 March 2020

Wyne P Lee

1 reference

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17 March 2020

Harvey Wong

1 reference

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17 March 2020

Wendy B Young

1 reference

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17 March 2020

Michael J Townsend

1 reference

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17 March 2020

Karin Reif

1 reference

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17 March 2020

Zora Modrusan

1 reference

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17 March 2020

publication date

6 April 2017

1 reference

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17 March 2020

1 reference

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17 March 2020

volume

1 reference

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17 March 2020

issue

1 reference

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17 March 2020

page(s)

e90111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase.

17 March 2020

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

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23 August 2017

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23 August 2017

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Type I interferon in systemic lupus erythematosus and other autoimmune diseases

23 August 2017

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Bruton's Tyrosine Kinase is involved in innate and adaptive immunity

23 August 2017

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Impaired clearance of dying cells in systemic lupus erythematosus.

23 August 2017

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Type I interferon correlates with serological and clinical manifestations of SLE

23 August 2017

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23 August 2017

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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

23 August 2017

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The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective

23 August 2017

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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

23 August 2017

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Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA

23 August 2017

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23 August 2017

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Towards new avenues in the management of lupus glomerulonephritis

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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B cell biology: implications for treatment of systemic lupus erythematosus

6 September 2017

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Targeting the SYK-BTK axis for the treatment of immunological and hematological disorders: recent progress and therapeutic perspectives

6 September 2017

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Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown.

6 September 2017

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An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

6 September 2017

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Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis

6 September 2017

1 reference

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Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation

6 September 2017

1 reference

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Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells

14 September 2017

1 reference

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Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

23 June 2018

1 reference

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Enhanced Expression of Bruton's Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis.

23 June 2018

1 reference

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Btk inhibition treats TLR7/IFN driven murine lupus.

1 September 2018

1 reference

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Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.

1 September 2018

1 reference

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Modeling the clinical phenotype of BTK inhibition in the mature murine immune system

1 September 2018

1 reference

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Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.

1 September 2018

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Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.

1 September 2018

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Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.

1 September 2018

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Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy

1 September 2018

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Systemic lupus erythematosus.

1 September 2018

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Extensions to gene set enrichment.

1 September 2018

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Defective FcgammaRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus

1 September 2018

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12 December 2020

Studies of congenic MRL-Ipr/Ipr.xid mice

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12 December 2020

FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis

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12 December 2020

Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family

1 reference

12 December 2020

IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice

1 reference

12 December 2020

10.1172/JCI.INSIGHT.90111

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

28405610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405610%20AND%20SRC:MED&resulttype=core&format=json