Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial (Q37735696)

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scientific article published on 26 October 2015

Language	Label	Description	Also known as
English	Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial	scientific article published on 26 October 2015

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scholarly article

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Europe PubMed Central

PMC publication ID

22 August 2017

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial (English)

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Europe PubMed Central

PMC publication ID

22 August 2017

phase III clinical trial

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activation syndrome

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based on heuristic

inferred from title

macrophage activation syndrome

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based on heuristic

inferred from title

Charles A. Dinarello

6

object named as

Charles A Dinarello

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Europe PubMed Central

22 August 2017

PMC publication ID

author name string

Bita Shakoory

1

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Europe PubMed Central

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22 August 2017

Joseph A Carcillo

2

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Europe PubMed Central

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22 August 2017

W Winn Chatham

3

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Europe PubMed Central

PMC publication ID

22 August 2017

Richard L Amdur

4

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Huaqing Zhao

5

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Europe PubMed Central

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22 August 2017

Randall Q Cron

7

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Europe PubMed Central

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22 August 2017

Steven M Opal

8

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Europe PubMed Central

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22 August 2017

language of work or name

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publication date

26 October 2015

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Europe PubMed Central

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22 August 2017

Critical Care Medicine

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Europe PubMed Central

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22 August 2017

44

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Europe PubMed Central

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22 August 2017

2

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Europe PubMed Central

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22 August 2017

275-281

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Europe PubMed Central

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22 August 2017

Macrophage activation syndrome secondary to human monocytic ehrlichiosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

High dose Anakinra for treatment of severe neonatal Kawasaki disease: a case report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Association between endothelial dysfunction and acute brain dysfunction during critical illness

1 reference

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22 August 2017

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Anakinra for rheumatoid arthritis: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Haemophagocytic syndromes in adults: current concepts and challenges ahead.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

The pathophysiology and treatment of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

An expanded definition of the adult respiratory distress syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Human leukocytic pyrogen: purification and development of a radioimmunoassay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

22 August 2017

Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

6 September 2017

Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

6 September 2017

Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

6 September 2017

Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Refractory macrophage activation syndrome in a patient with SLE and APLA syndrome - Successful use of PET- CT and Anakinra in its diagnosis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Secondary hemophagocytic lymphohistiocytosis and severe sepsis/ systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

A case of macrophage activation syndrome successfully treated with anakinra

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

14 September 2017

Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

28 September 2017

Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocyt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

23 June 2018

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

23 June 2018

Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

23 June 2018

Higher-dose Anakinra is effective in a case of medically refractory macrophage activation syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

1 September 2018

Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

1 September 2018

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5378312

3 December 2018

High elevated ferritin levels and the diagnosis of HLH/Sepsis/SIRS/MODS/MAS

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage activation syndrome treated with anakinra

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and Sustained Remission of Systemic Juvenile Idiopathic Arthritis-Associated Macrophage Activation Syndrome Through Treatment With Anakinra and Corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic role of anakinra, an interleukin-1 receptor antagonist, in the management of secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction/macrophage activating syndrome in critically ill children*

1 reference

https://pubmed.ncbi.nlm.nih.gov/26584195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/CCM.0000000000001402

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

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