Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice (Q37689672)

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scientific article published on 15 January 2014

Language	Label	Description	Also known as
English	Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice	scientific article published on 15 January 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice (English)

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

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Braden C Fleming

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Richard M Terek

object named as

Richard Terek

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object named as

Ge Zhang

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author name string

Jingming Zhou

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Europe PubMed Central

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22 August 2017

Qian Chen

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Europe PubMed Central

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22 August 2017

Beate Lanske

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Europe PubMed Central

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22 August 2017

Xiaochun Wei

6

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Europe PubMed Central

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22 August 2017

Shaowei Wang

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Europe PubMed Central

PMC publication ID

22 August 2017

Kai Li

9

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Europe PubMed Central

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22 August 2017

Lei Wei

10

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Europe PubMed Central

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22 August 2017

publication date

15 January 2014

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Europe PubMed Central

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22 August 2017

Arthritis Research and Therapy

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Europe PubMed Central

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22 August 2017

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Europe PubMed Central

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22 August 2017

1

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Europe PubMed Central

PMC publication ID

22 August 2017

R11

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22 August 2017

Synthesis and biological evaluation of a new polymeric conjugate and nanocarrier with osteotropic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Age-related changes in the musculoskeletal system and the development of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila

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23 August 2017

Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

1 reference

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23 August 2017

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Shedding light onto live molecular targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 August 2017

Cyclopamine-induced holoprosencephaly and associated craniofacial malformations in the golden hamster: anatomic and molecular events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

6 September 2017

Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

14 September 2017

Indian hedgehog roles in post-natal TMJ development and organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 June 2018

Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 June 2018

Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 June 2018

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 June 2018

Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

23 June 2018

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

Genetics of osteoarthritis: early developmental clues to an old disease.

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1 September 2018

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978435

1 September 2018

Osteoarthritis cartilage histopathology: grading and staging.

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1 September 2018

Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.

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1 September 2018

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

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1 September 2018

Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis

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1 September 2018

Mechanical load and primary guinea pig osteoarthrosis

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1 September 2018

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence

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12 December 2020

based on heuristic

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Correlation of morphologic and biochemical changes in the natural history of spontaneous osteoarthrosis in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type X collagen expression in osteoarthritic and rheumatoid articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritis development in novel experimental mouse models induced by knee joint instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of collagen types I, II, III, and X in human osteophytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24428864

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

PMC publication ID

22 August 2017

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PMC publication ID

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Europe PubMed Central

PMC publication ID

22 August 2017

PubMed publication ID

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Europe PubMed Central

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22 August 2017

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