Targeting DAX-1 in embryonic stem cells and cancer (Q37670246)

21 August 2017

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title

Targeting DAX-1 in embryonic stem cells and cancer (English)

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21 August 2017

Enzo Lalli

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21 August 2017

Javier Alonso

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21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Therapeutic Targets

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

169-177

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A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal

21 August 2017

cites work

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An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

21 January 2018

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Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism

21 January 2018

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Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin production

21 January 2018

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Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience

21 January 2018

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A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation

21 January 2018

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A unified nomenclature system for the nuclear receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

SF-1 a key player in the development and differentiation of steroidogenic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dax-1 as one of the target genes of Ad4BP/SF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dax1 antagonizes Sry action in mammalian sex determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Hypogonadotropic hypogonadism in a female caused by an X-linked recessive mutation in the DAX1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Role of Ahch in gonadal development and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dax1 regulates testis cord organization during gonadal differentiation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

Dax1 is required for testis determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

A phenotypic spectrum of sexual development in Dax1 (Nr0b1)-deficient mice: consequence of the C57BL/6J strain on sex determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

A protein interaction network for pluripotency of embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

An extended transcriptional network for pluripotency of embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903531454

Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dax-1 knockdown in mouse embryonic stem cells induces loss of pluripotency and multilineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Expression profiling of nuclear receptors in human and mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Extracellular matrix and hormones modulate DAX-1 localization in the human fetal adrenal gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Heat shock affects trafficking of DAX-1 by inducing its rapid and reversible cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 expression in human adrenocortical neoplasms: implications for steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: possible implications in steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

A matter of dosage: SF-1 in adrenocortical development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Nuclear receptor DAX‐1 in human common epithelial ovarian carcinoma: An independent prognostic factor of clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-alpha, ER-beta and androgen receptor status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Orphan nuclear receptor DAX-1 in human endometrium and its disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Nuclear receptor DAX1 in human prostate cancer: a novel independent biological modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 expression is regulated during mammary epithelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

SP analysis may be used to identify cancer stem cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Tumorigenic role of orphan nuclear receptor NR0B1 in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Biology of EWS/ETS fusions in Ewing's family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Strategies and new developments in the generation of patient-specific pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-chromosome, gene 1) selectively inhibits transactivation but not transrepression mediated by the glucocorticoid receptor in a LXXLL-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Repressors of androgen and progesterone receptor action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903531454

10.1517/14728220903531454

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

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