Subcellular targeting strategies for drug design and delivery (Q37665298)

21 August 2017

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title

Subcellular targeting strategies for drug design and delivery (English)

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21 August 2017

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21 August 2017

Hans-Joachim Knölker

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21 August 2017

Kai Simons

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21 August 2017

publication date

1 January 2010

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Nature Reviews Drug Discovery

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

29-42

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Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.

21 August 2017

cites work

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Lipid and cholesterol trafficking in NPC.

21 January 2018

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Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases

21 January 2018

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21 January 2018

12 December 2020

Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent

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A brief history of novel drug discovery technologies

21 January 2018

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Drug delivery. Drugs on target

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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The rise and rise of drug delivery

31 March 2020

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Mechanisms of pathogen entry through the endosomal compartments

31 March 2020

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Functional rafts in cell membranes

31 March 2020

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Rab proteins as membrane organizers

31 March 2020

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CD95 Signaling via Ceramide-rich Membrane Rafts

31 March 2020

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Dimerization of cell surface receptors in signal transduction

31 March 2020

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G-protein-coupled receptor heterodimerization modulates receptor function

31 March 2020

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Membrane-assisted molecular mechanism of neurokinin receptor subtype selection.

31 March 2020

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Why cytoplasmic signalling proteins should be recruited to cell membranes.

31 March 2020

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31 March 2020

HIV entry inhibitors.

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Emerging drug targets for antiretroviral therapy

31 March 2020

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Membrane-anchored peptide inhibits human immunodeficiency virus entry

31 March 2020

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Membrane-anchored inhibitory peptides capture human immunodeficiency virus type 1 gp41 conformations that engage the target membrane prior to fusion

31 March 2020

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Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

31 March 2020

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HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

31 March 2020

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Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo

31 March 2020

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

31 March 2020

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Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein

31 March 2020

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Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.

31 March 2020

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G-protein-coupled receptor oligomerization and its potential for drug discovery

31 March 2020

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Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

31 March 2020

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Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation

31 March 2020

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Endosomes as a route for drug delivery in the real world

31 March 2020

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Membrane traffic in sphingolipid storage diseases

31 March 2020

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

31 March 2020

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Cargo recognition during clathrin-mediated endocytosis: a team effort

31 March 2020

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31 March 2020

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Regulated portals of entry into the cell

31 March 2020

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Clathrin-coated vesicle formation and protein sorting: an integrated process

31 March 2020

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31 March 2020

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Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11

31 March 2020

1 reference

Not just a sink: endosomes in control of signal transduction

31 March 2020

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Signal transduction and endocytosis: close encounters of many kinds

31 March 2020

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The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

31 March 2020

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Signaling on the endocytic pathway

31 March 2020

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APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

31 March 2020

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Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.

31 March 2020

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Sara endosomes and the maintenance of Dpp signaling levels across mitosis.

31 March 2020

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Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

31 March 2020

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Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.

31 March 2020

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How Viruses Enter Animal Cells

31 March 2020

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31 March 2020

Virus entry: open sesame

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Membrane traffic exploited by protein toxins

31 March 2020

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Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells

31 March 2020

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Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway

31 March 2020

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Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2.

31 March 2020

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Pathways of clathrin-independent endocytosis

31 March 2020

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GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.

31 March 2020

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Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1.

31 March 2020

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Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

31 March 2020

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pH-sensitive toxins: interactions with membrane bilayers and application to drug delivery

31 March 2020

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Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins

31 March 2020

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Exploitation of intracellular pH gradients in the cellular delivery of macromolecules

31 March 2020

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Beta-secretase (BACE) as a drug target for Alzheimer's disease

31 March 2020

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

31 March 2020

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A chimeric saporin-transferrin conjugate compared to ricin toxin: role of the carrier in intracellular transport and toxicity.

31 March 2020

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Folate-targeted chemotherapy

31 March 2020

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Drug targeting using low density lipoprotein (LDL): physicochemical factors affecting drug loading into LDL particles.

31 March 2020

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Folate receptor-mediated drug targeting: from therapeutics to diagnostics

31 March 2020

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Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells.

31 March 2020

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Targeted drug delivery via folate receptors

31 March 2020

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Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells

31 March 2020

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Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells

31 March 2020

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Brain targeting using novel lipid nanovectors

31 March 2020

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Transferrin-conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain

31 March 2020

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Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).

31 March 2020

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The cell biology of lysosomal storage disorders

31 March 2020

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Enzyme therapy for lysosomal storage disease: principles, practice, and prospects

31 March 2020

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Toward enzyme therapy for lysosomal storage diseases

31 March 2020

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Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors

31 March 2020

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Dexamethasone-Mediated Up-Regulation of the Mannose Receptor Improves the Delivery of Recombinant Glucocerebrosidase to Gaucher Macrophages

31 March 2020

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Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

31 March 2020

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Protein toxins: intracellular trafficking for targeted therapy.

31 March 2020

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The use of Shiga-like toxin 1 in cancer therapy

31 March 2020

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Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins.

31 March 2020

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Glucosylceramide modulates membrane traffic along the endocytic pathway

31 March 2020

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Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

31 March 2020

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Cellular uptake of the tat protein from human immunodeficiency virus

31 March 2020

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Intercellular trafficking and protein delivery by a herpesvirus structural protein

31 March 2020

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The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

31 March 2020

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A Comprehensive Model for the Cellular Uptake of Cationic Cell-penetrating Peptides

31 March 2020

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Transmembrane delivery of the cell-penetrating peptide conjugated semiconductor quantum dots

31 March 2020

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Polyarginine segments in block copolypeptides drive both vesicular assembly and intracellular delivery.

31 March 2020

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Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.

31 March 2020

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Stearylated arginine-rich peptides: a new class of transfection systems

31 March 2020

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The design and synthesis of polymers for eukaryotic membrane disruption.

31 March 2020

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Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins

31 March 2020

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GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

31 March 2020

1 reference

Intracellular trafficking of adenovirus: many means to many ends

31 March 2020

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Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

31 March 2020

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Endosome-to-cytosol transport of viral nucleocapsids

31 March 2020

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Designing polymer conjugates as lysosomotropic nanomedicines

31 March 2020

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Selective disruption of early/recycling endosomes: release of disulfide-linked cargo mediated by a N-alkyl-3beta-cholesterylamine-capped peptide

31 March 2020

1 reference

Knocking down barriers: advances in siRNA delivery

31 March 2020

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

31 March 2020

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

31 March 2020

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Interfering with disease: a progress report on siRNA-based therapeutics

31 March 2020

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Intracellular trafficking and transgene expression of viral and non-viral gene vectors

31 March 2020

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Caveolae/raft-dependent endocytosis

31 March 2020

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Nonviral gene therapy: promises and challenges

31 March 2020

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Polyethylenimine-based intravenous delivery of transgenes to mouse lung.

31 March 2020

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pH-sensitive, cationic liposomes: a new synthetic virus-like vector

31 March 2020

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Nanomedicine: developing smarter therapeutic and diagnostic modalities

31 March 2020

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The specific delivery of proteins to human liver cells by engineered bio-nanocapsules

31 March 2020

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Nanoparticles for the delivery of genes and drugs to human hepatocytes

31 March 2020

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Impact of nanotechnology on drug delivery.

31 March 2020

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Nanocarriers as an emerging platform for cancer therapy

31 March 2020

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Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

31 March 2020

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Peptoidic amino- and guanidinium-carrier systems: targeted drug delivery into the cell cytosol or the nucleus

31 March 2020

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Mitochondrion of protozoan parasite emerges as potent therapeutic target: exciting drugs are on the horizon

31 March 2020

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Targeting large molecules to mitochondria

31 March 2020

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Approaches to mitochondrially mediated cancer therapy

31 March 2020

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Chemotherapy: targeting the mitochondrial cell death pathway

31 March 2020

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Targeting lipophilic cations to mitochondria.

31 March 2020

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Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases

31 March 2020

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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

31 March 2020

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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

31 March 2020

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Phosphoinositides in cell regulation and membrane dynamics

31 March 2020

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Lipid signalling in disease.

31 March 2020

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Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease

31 March 2020

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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

31 March 2020

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Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.

31 March 2020

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Translational control of localized mRNAs: restricting protein synthesis in space and time

31 March 2020

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A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

31 March 2020

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Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

31 March 2020

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Silencing by small RNAs is linked to endosomal trafficking

31 March 2020

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Subcellular neuropharmacology: the importance of intracellular targeting

31 March 2020

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Lipoprotein particles are required for Hedgehog and Wingless signalling

31 March 2020

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Exosomes: a bubble ride for prions?

31 March 2020

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Targeted delivery of proteins across the blood-brain barrier

31 March 2020

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Direct observation of the nanoscale dynamics of membrane lipids in a living cell

31 March 2020

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Assembly and budding of influenza virus

31 March 2020

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Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells

31 March 2020

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Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection

31 March 2020

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Targeting lipids to prevent HIV infection

31 March 2020

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Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel

31 March 2020

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HIV: a raft-targeting approach for prevention and therapy using plant-derived compounds (review).

31 March 2020

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Influenza viruses select ordered lipid domains during budding from the plasma membrane

31 March 2020

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Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 protein

31 March 2020

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Lipid rafts and malaria parasite infection of erythrocytes

31 March 2020

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The role of cholesterol and glycosylphosphatidylinositol-anchored proteins of erythrocyte rafts in regulating raft protein content and malarial infection

31 March 2020

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Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

31 March 2020

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Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

31 March 2020

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Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein

31 March 2020

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Lipid segregation and IgE receptor signaling: a decade of progress

31 March 2020

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Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcepsilonRI.

31 March 2020

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

31 March 2020

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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

31 March 2020

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

31 March 2020

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Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails.

31 March 2020

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31 March 2020

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Differential sorting and fate of endocytosed GPI-anchored proteins

31 March 2020

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Membrane lipids and vesicular traffic.

31 March 2020

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Binding of verocytotoxin 1 to its receptor is influenced by differences in receptor fatty acid content

31 March 2020

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Endocytic trafficking of sphingomyelin depends on its acyl chain length

31 March 2020

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Synthetic mimics of small Mammalian cell surface receptors

31 March 2020

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Transferrin directed delivery of adriamycin to human cells.

31 March 2020

1 reference

12 December 2020

Glycosphingolipid receptor function is modified by fatty acid content. Verotoxin 1 and verotoxin 2c preferentially recognize different globotriaosyl ceramide fatty acid homologues

1 reference

12 December 2020

Protein targeting (Nobel lecture).

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12 December 2020

Photochemical internalization: a novel technology for delivery of macromolecules into cytosol

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12 December 2020

Recombinant toxins for the treatment of cancer

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12 December 2020

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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12 December 2020

Uptake and concentration of bioactive macromolecules by K562 cells via the transferrin cycle utilizing an acid-labile transferrin conjugate

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12 December 2020

Diffusion control of protein phosphorylation in signal transduction pathways

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12 December 2020

How do peptides interact with lipid membranes and how does this affect their biological activity?

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12 December 2020

Identifiers

DOI

10.1038/NRD2897

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21 August 2017

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