Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection (Q37643636)

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scientific article published on 23 December 2013

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English	Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection	scientific article published on 23 December 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1 reference

based on heuristic

inferred from title

Leishmania donovani

object named as

Leishmania donovani

1 reference

based on heuristic

inferred from title

object named as

Najma Rachidi

1

0 references

object named as

Eric Prina

6

0 references

Cedric Notredame

object named as

Cedric Notredame

8

0 references

9

object named as

Laurent Meijer

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

author name string

Jean François Taly

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Emilie Durieu

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Olivier Leclercq

4

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Nathalie Aulner

5

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Pascale Pescher

7

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Gerald F Späth

10

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

0 references

publication date

23 December 2013

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

58

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1501-1515

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Illustration of SSMD, z Score, SSMD*, z* Score, and t Statistic for Hit Selection in RNAi High-Throughput Screens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Leishmania Exosomes Modulate Innate and Adaptive Immune Responses through Effects on Monocytes and Dendritic Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Upcoming challenges for multiple sequence alignment methods in the high-throughput era

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Identification of phosphorylated proteins in erythrocytes infected by the human malaria parasite Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Rapid fluorescent assay for screening drugs on Leishmania amastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Proteomic analysis of the secretome of Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

The selectivity of protein kinase inhibitors: a further update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Clustal W and Clustal X version 2.0

1 reference

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23 August 2017

LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Advances in leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Protein database searches using compositionally adjusted substitution matrices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Protein kinases as targets for anti-parasitic chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

The Jalview Java alignment editor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

1 reference

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23 August 2017

Crystal structure of a conformation-selective casein kinase-1 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

23 August 2017

Leishmaniasis: complexity at the host-pathogen interface.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

6 September 2017

Drug discovery and the human kinome: Recent trends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

6 September 2017

Release of Ecto-protein Kinases by the Protozoan ParasiteLeishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

6 September 2017

Effect of pH and temperature on protein kinase release by Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

14 September 2017

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

28 September 2017

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

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28 September 2017

Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the malaria parasite, Plasmodium falciparum. Stage-specific expression of the gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

25 June 2018

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

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1 September 2018

Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1alpha

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

1 September 2018

Phosphoproteomic analysis of Leishmania donovani pro- and amastigote stages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3957854

1 September 2018

Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity

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1 September 2018

Purification of CK1 by affinity chromatography on immobilised axin

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1 September 2018

Inhibitors of casein kinase 1 block the growth of Leishmania major promastigotes in vitro.

1 reference

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1 September 2018

Characterization of two T. gondii CK1 isoforms

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1 September 2018

An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans.

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1 September 2018

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi.

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1 September 2018

Biochemical and enzymatic characterization of a partially purified casein kinase-1 like activity from Trypanosoma cruzi

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1 September 2018

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

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1 September 2018

Characterization of developmentally-regulated activities in axenic amastigotes of Leishmania donovani.

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1 September 2018

Growth at acidic pH induces an amastigote stage-specific protein in Leishmania promastigotes

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366737

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gel free analysis of the proteome of intracellular Leishmania mexicana

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366737

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.02022-13

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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