Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer (Q37634598)

21 August 2017

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title

Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer (English)

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21 August 2017

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21 August 2017

Yasushi Yatabe

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21 August 2017

language of work or name

English

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publication date

18 November 2009

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21 August 2017

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21 August 2017

volume

277

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21 August 2017

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page(s)

301-308

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The discovery of receptor tyrosine kinases: targets for cancer therapy

21 August 2017

cites work

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ERBB receptors and cancer: the complexity of targeted inhibitors

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The epidermal growth factor receptor ligands at a glance

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials

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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 January 2018

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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

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Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer.

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EGFR mutation is specific for terminal respiratory unit type adenocarcinoma

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

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Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer.

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Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

21 January 2018

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EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.

21 January 2018

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Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese

21 January 2018

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10.1111/J.1742-4658.2009.07448.X

21 January 2018

Identifiers

DOI

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21 August 2017

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