c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis (Q37629637)

21 August 2017

title

c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis (English)

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21 August 2017

Ryan H Cunnington

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21 August 2017

Mansoreh Nazari

series ordinal

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21 August 2017

Ian M C Dixon

series ordinal

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21 August 2017

publication date

1 October 2009

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Canadian Journal of Physiology and Pharmacology

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

764-772

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TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

21 August 2017

cites work

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c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

21 January 2018

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Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth

21 January 2018

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The protooncogene Ski controls Schwann cell proliferation and myelination

21 January 2018

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Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases.

21 January 2018

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Growth properties and biochemical characterization of collagens synthesized by adult rat heart fibroblasts in culture

21 January 2018

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Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

21 January 2018

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

21 January 2018

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Muscle hypertrophy induced by the Ski protein: cyto-architecture and ultrastructure.

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Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences

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Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle

21 January 2018

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Regulation of collagen degradation in the rat myocardium after infarction

21 January 2018

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Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

21 January 2018

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FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

21 January 2018

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Induction of the mammalian node requires Arkadia function in the extraembryonic lineages

21 January 2018

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Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart.

21 January 2018

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Administration of granulocyte colony-stimulating factor after myocardial infarction enhances the recruitment of hematopoietic stem cell-derived myofibroblasts and contributes to cardiac repair

21 January 2018

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The cellular derivation and the life span of the myofibroblast

21 January 2018

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21 January 2018

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Scar remodeling and transmural deformation after infarction in the pig.

21 January 2018

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

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Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

21 January 2018

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The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm

21 January 2018

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Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

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Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

21 January 2018

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Induction of cardiac fibrosis by transforming growth factor-beta(1).

21 January 2018

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

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Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

21 January 2018

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Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis

21 January 2018

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Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition

21 January 2018

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Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

21 January 2018

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

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The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis

21 January 2018

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Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover

21 January 2018

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Ocular abnormalities in mice lacking the Ski proto-oncogene

21 January 2018

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Bone marrow-derived cells contribute to infarct remodelling

21 January 2018

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Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

21 January 2018

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Nuclear and cytoplasmic c-Ski differently modulate cellular functions

21 January 2018

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

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Arkadia enhances nodal-related signalling to induce mesendoderm

21 January 2018

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Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

21 January 2018

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Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta

21 January 2018

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Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

21 January 2018

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Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications

21 January 2018

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Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves

21 January 2018

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Mechanisms of myofibroblast activity and phenotypic modulation.

21 January 2018

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The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.

21 January 2018

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Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice

21 January 2018

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Possible role for the c-ski gene in the proliferation of myogenic cells in regenerating skeletal muscles of rats

21 January 2018

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Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

21 January 2018

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SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

21 January 2018

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Characterization of chicken c-ski oncogene products expressed by retrovirus vectors

21 January 2018

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c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

21 January 2018

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Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

21 January 2018

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Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication

21 January 2018

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

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Myofibroblasts and mechano-regulation of connective tissue remodelling

21 January 2018

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

21 January 2018

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Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction

21 January 2018

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Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart

21 January 2018

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Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms

21 January 2018

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Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis

21 January 2018

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The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor

21 January 2018

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Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

21 January 2018

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Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts

21 January 2018

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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

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Elevation of Expression of Smads 2, 3, and 4, Decorin and TGF-βin the Chronic Phase of Myocardial Infarct Scar Healing

21 January 2018

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Expression of Gi-2α and Gsα in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction

21 January 2018

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Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y09-076

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21 August 2017

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