Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy (Q37619757)

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scientific article published on 23 July 2016

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English	Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy	scientific article published on 23 July 2016

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21 August 2017

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy (English)

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21 August 2017

chemoradiotherapy

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11 June 2020

Panagiotis Balermpas

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11 June 2020

Emmanouil Fokas

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Emmanouil Fokas

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11 June 2020

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Franz Rödel

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11 June 2020

Christina Helmke

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11 June 2020

Ulrike Wieland

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11 June 2020

Margret Rave-Fränk

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11 June 2020

Julia Kitz

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11 June 2020

Yves Matthess

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11 June 2020

Monika Raab

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11 June 2020

Klaus Strebhardt

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11 June 2020

Claus Rödel

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11 June 2020

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23 July 2016

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21 August 2017

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11 June 2020

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11 June 2020

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11 June 2020

53339-53349

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11 June 2020

Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection

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23 August 2017

Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer

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23 August 2017

Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment

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23 August 2017

HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53

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Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

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Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.

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Enhanced radiation sensitivity in HPV-positive head and neck cancer

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The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

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23 August 2017

Human papillomavirus oncoproteins: pathways to transformation

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Human papillomavirus and survival of patients with oropharyngeal cancer.

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BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

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23 August 2017

Targeting cancer with small molecule kinase inhibitors

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23 August 2017

Identification of novel p53 target genes in ionizing radiation response.

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Polo-like kinases and oncogenesis

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23 August 2017

Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues

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23 August 2017

Yeast polo-like kinases: functionally conserved multitask mitotic regulators

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23 August 2017

Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma

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23 August 2017

Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2

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23 August 2017

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

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23 August 2017

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

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23 August 2017

The biochemistry of apoptosis

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23 August 2017

Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

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23 August 2017

PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer

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23 August 2017

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

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23 August 2017

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

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The role of Plk3 in oncogenesis

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6 September 2017

Human papillomavirus oncoproteins and apoptosis (Review).

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6 September 2017

HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

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6 September 2017

Caspase-3 activity predicts local recurrence in rectal cancer

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6 September 2017

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.

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14 September 2017

Radiosensitization of Oropharyngeal Squamous Cell Carcinoma Cells by Human Papillomavirus 16 Oncoprotein E6∗I

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14 September 2017

Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT.

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14 September 2017

Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells

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Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility

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Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions

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Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response.

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14 September 2017

Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes

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Tumor-infiltrating CD8(+) T lymphocytes associated with clinical outcome in anal squamous cell carcinoma

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CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).

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Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy

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25 June 2018

Human papillomavirus genotyping and p16 expression as prognostic factors for patients with American Joint Committee on Cancer stages I to III carcinoma of the anal canal

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25 June 2018

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

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Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery.

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Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma.

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Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

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1 September 2018

Prognostic value of apoptosis-regulating protein expression in anal squamous cell carcinoma.

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1 September 2018

Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer

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1 September 2018

Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck

1 reference

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12 December 2020

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10.18632/ONCOTARGET.10801

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11 June 2020

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11 June 2020

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11 June 2020

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