Titin-based mechanical signalling in normal and failing myocardium (Q37565374)

21 August 2017

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title

Titin-based mechanical signalling in normal and failing myocardium (English)

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21 August 2017

Martina Krüger

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21 August 2017

Wolfgang A Linke

series ordinal

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21 August 2017

publication date

1 April 2009

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Journal of Molecular and Cellular Cardiology

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

490-498

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The giant protein titin: a major player in myocardial mechanics, signaling, and disease

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin: major myofibrillar components of striated muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Basis of passive tension and stiffness in isolated rabbit myofibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Passive and active tension in single cardiac myofibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The physiological role of titin in striated muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin develops restoring force in rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Damped elastic recoil of the titin spring in myofibrils of human myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Length modulation of active force in rat cardiac myocytes: is titin the sensor?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Length dependence of tension generation in rat skinned cardiac muscle: role of titin in the Frank-Starling mechanism of the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanism of the Frank-Starling law--a simulation study with a novel cardiac muscle contraction model that includes titin and troponin I

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Troponin and titin coordinately regulate length-dependent activation in skinned porcine ventricular muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin: a molecular control freak

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Striated muscle cytoarchitecture: an intricate web of form and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Cardiac myofibrillogenesis inside intact embryonic hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The sensitive giant: the role of titin-based stretch sensing complexes in the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

From A to Z and back? Multicompartment proteins in the sarcomere.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Biosynthesis of titin in cultured skeletal muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin isoform changes in rat myocardium during development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Plasticity of cardiac titin/connectin in heart development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin isoform switch in ischemic human heart disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin isoforms, extracellular matrix, and global chamber remodeling in experimental dilated cardiomyopathy: functional implications and mechanistic insight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Alterations in the determinants of diastolic suction during pacing tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Impact of diabetes on cardiac structure and function: the strong heart study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Diabetic cardiomyopathy revisited

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Impact of diabetes and hypertension on the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Diastolic Stiffness of the Failing Diabetic Heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Cardiomyocyte Stiffness in Diastolic Heart Failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanical Strength of the Titin Z1Z2-Telethonin Complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Actin-titin interaction in cardiac myofibrils: probing a physiological role

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The sarcomeric Z-disc: a nodal point in signalling and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Dual level of interactions between calcineurin and PKC-ε in cardiomyocyte stretch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Regulation of cardiac hypertrophy by intracellular signalling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

MDM2 interacts with and downregulates a sarcomeric protein, TCAP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Costameres, focal adhesions, and cardiomyocyte mechanotransduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Focal adhesions: paradigm for a signaling nexus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Obscurin is a ligand for small ankyrin 1 in skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mapping the binding site on small ankyrin 1 for obscurin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Calpain 1 binding capacities of the N1-line region of titin are significantly enhanced by physiological concentrations of calcium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Association of the chaperone alphaB-crystallin with titin in heart muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Calpain 3: a key regulator of the sarcomere?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Structural basis for activation of the titin kinase domain during myofibrillogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The kinase domain of titin controls muscle gene expression and protein turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mechanoenzymatics of titin kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titin mutations as the molecular basis for dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Truncating mutations in C-terminal titin may cause more severe tibial muscular dystrophy (TMD).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Titinopathies and extension of the M-line mutation phenotype beyond distal myopathy and LGMD2J.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Tibial muscular dystrophy in a Belgian family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

10.1016/J.YJMCC.2009.01.004

7 January 2021

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DOI

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21 August 2017

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