Less Smad2 is good for you! A scientific update on coffee's liver benefits (Q37554158)

21 August 2017

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title

Less Smad2 is good for you! A scientific update on coffee's liver benefits (English)

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21 August 2017

Olav A Gressner

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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21 August 2017

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

970-978

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Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?

21 August 2017

cites work

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Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States

21 January 2018

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Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States

21 January 2018

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Coffee and risk of death from hepatocellular carcinoma in a large cohort study in Japan

21 January 2018

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Coffee Consumption and Risk of Liver Cancer: A Meta-Analysis

21 January 2018

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Plasma and salivary pharmacokinetics of caffeine in man

21 January 2018

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21 January 2018

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Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism

21 January 2018

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Caffeine biotransformation in human hepatocyte lines derived from normal liver tissue

21 January 2018

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Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation

21 January 2018

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The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease

21 January 2018

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Studies on the mechanism of caffeine action in alveolar macrophages: caffeine elevates cyclic adenosine monophosphate level and prostaglandin synthesis

21 January 2018

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Caffeine as a psychomotor stimulant: mechanism of action.

21 January 2018

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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

21 January 2018

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Transcriptional regulation by cyclic AMP

21 January 2018

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Coupling gene expression to cAMP signalling: role of CREB and CREM.

21 January 2018

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Transcriptional regulation by the phosphorylation-dependent factor CREB

21 January 2018

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Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

21 January 2018

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Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis

21 January 2018

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All in the CCN family: essential matricellular signaling modulators emerge from the bunker

21 January 2018

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Connective tissue growth factor: what's in a name?

21 January 2018

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Structural and functional properties of CCN proteins

21 January 2018

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Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes

21 January 2018

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Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

21 January 2018

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Mechanisms of hepatic fibrogenesis

21 January 2018

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Liver fibrosis: from the bench to clinical targets

21 January 2018

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Transforming growth factor beta and the liver

21 January 2018

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Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3.

21 January 2018

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The TGF-beta paradox in human cancer: an update

21 January 2018

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TGF-beta-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes.

21 January 2018

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Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis.

21 January 2018

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TGF-beta control of cell proliferation

21 January 2018

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TGF-beta1: immunosuppressant and viability factor for T lymphocytes

21 January 2018

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Role of transforming growth factor Beta in human cancer

21 January 2018

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Bone morphogenetic proteins

21 January 2018

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BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

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Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

21 January 2018

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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

21 January 2018

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Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

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CTGF inhibits BMP-7 signaling in diabetic nephropathy

21 January 2018

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Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

21 January 2018

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Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer

21 January 2018

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Expression of connective tissue growth factor (CTGF/CCN2) in head and neck squamous cell carcinoma.

21 January 2018

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Connective tissue growth factor is an indicator of bone involvement in multiple myeloma, but matrix metalloproteinase-9 is not.

21 January 2018

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High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia

21 January 2018

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CTGF, intestinal stellate cells and carcinoid fibrogenesis

21 January 2018

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Expression of connective tissue growth factor in experimental rat and human liver fibrosis

21 January 2018

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siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats.

21 January 2018

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Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways

21 January 2018

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

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TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

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Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control

21 January 2018

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

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PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

21 January 2018

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Differential regulation of proteasome activity in the nucleus and the synaptic terminals

21 January 2018

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Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation

21 January 2018

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Intraperitoneal application of caffeine prevents D-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat.

21 January 2018

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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

21 January 2018

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Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

21 January 2018

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The Starbuck stops here: it's a Smad world

21 January 2018

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The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

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Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers

21 January 2018

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7 January 2021

Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan

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7 January 2021

Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations

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7 January 2021

Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle.

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7 January 2021

Differential effects of TGF-β on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes

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7 January 2021

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

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7 January 2021

Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats

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7 January 2021

Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway

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7 January 2021

Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland

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7 January 2021

Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2

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7 January 2021

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

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7 January 2021

Identifiers

DOI

10.1002/HEP.23097

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21 August 2017

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