Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors (Q37544686)

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scientific article published on 11 May 2016

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English	Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors	scientific article published on 11 May 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

5199138

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20 August 2017

title

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors (English)

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5199138

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main subject

pharmacology

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author

Yves Pommier

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Yves Pommier

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Europe PubMed Central

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20 August 2017

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5199138

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Shivaani Kummar

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Alice Chen

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Martin Gutierrez

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Thomas D Pfister

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Lihua Wang

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Christophe Redon

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William M Bonner

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William Yutzy

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Yiping Zhang

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Robert J Kinders

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Jiuping Ji

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Deborah Allen

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Joseph M Covey

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Julie L Eiseman

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Julianne L Holleran

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Jan H Beumer

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Larry Rubinstein

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Jerry Collins

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Joseph Tomaszewski

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Ralph Parchment

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James H Doroshow

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publication date

11 May 2016

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20 August 2017

published in

Cancer Chemotherapy and Pharmacology

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volume

78

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issue

1

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page(s)

73-81

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Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs

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Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer

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Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).

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Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues

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Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I

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The Use of Gamma-H2AX as a Biodosimeter for Total-Body Radiation Exposure in Non-Human Primates

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Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity

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Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776.

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Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

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Identifiers

DOI

10.1007/S00280-016-2998-6

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Europe PubMed Central

PMC publication ID

5199138

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20 August 2017

PMC publication ID

5199138

1 reference

stated in

Europe PubMed Central

PMC publication ID

5199138

retrieved

20 August 2017

PubMed publication ID

27169793

1 reference

stated in

Europe PubMed Central

PMC publication ID

5199138

retrieved

20 August 2017

 

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