Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs (Q37521059)

20 August 2017

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title

Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs (English)

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20 August 2017

author name string

Alice Cristina Rodrigues

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20 August 2017

Mario Hiroyuki Hirata

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20 August 2017

Rosario Dominguez Crespo Hirata

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20 August 2017

publication date

1 June 2009

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20 August 2017

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20 August 2017

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20 August 2017

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20 August 2017

page(s)

1007-1016

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HMG-CoA reductase inhibitors and P-glycoprotein modulation

20 August 2017

cites work

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Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion

21 January 2018

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Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

21 January 2018

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Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport

21 January 2018

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Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells.

21 January 2018

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Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses

21 January 2018

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P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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The effect of rifampin treatment on intestinal expression of human MRP transporters

21 January 2018

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Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

21 January 2018

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Therapeutic implications of the MDR-1 gene

21 January 2018

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P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice

21 January 2018

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ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment

21 January 2018

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Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms.

21 January 2018

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Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

21 January 2018

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Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

21 January 2018

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Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy

21 January 2018

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An association study of 43 SNPs in 16 candidate genes with atorvastatin response

21 January 2018

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Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors

21 January 2018

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

21 January 2018

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Efficacy and long-term adverse effect pattern of lovastatin

21 January 2018

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Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro

21 January 2018

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Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter

21 January 2018

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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

21 January 2018

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Reversal of P-glycoprotein-mediated multidrug resistance by cholesterol derived from low density lipoprotein in a vinblastine-resistant human lymphoblastic leukemia cell line

21 January 2018

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Plasma LDL cholesterol has no impact on P-glycoprotein (MDR1/ABCB1) activity in human peripheral blood mononuclear cells

21 January 2018

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The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells

21 January 2018

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Influence of diet on experimental toxicity of amphotericin B deoxycholate

21 January 2018

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Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B.

21 January 2018

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists

21 January 2018

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Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes

21 January 2018

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Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine

21 January 2018

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Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation

21 January 2018

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Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

21 January 2018

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Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/PGS.09.18

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20 August 2017

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