Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse (Q37481427)

20 August 2017

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title

Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse (English)

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20 August 2017

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Anders Rane

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20 August 2017

Lena Ekström

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20 August 2017

Jenny J Schulze

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20 August 2017

language of work or name

English

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publication date

1 July 2009

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Expert Opinion on Drug Metabolism & Toxicology

20 August 2017

published in

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20 August 2017

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20 August 2017

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20 August 2017

page(s)

731-744

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The use and misuse of androgens

20 August 2017

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More than eight years' hands-on experience with the novel long-acting parenteral testosterone undecanoate

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Hormone abuse in sports: the antidoping perspective

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Androgen abuse in sports

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NOTE ON THE EFFECTS PRODUCED ON MAN BY SUBCUTANEOUS INJECTIONS OF A LIQUID OBTAINED FROM THE TESTICLES OF ANIMALS

21 January 2018

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Anabolic Steroids: Doctors Denounce Them, but Athletes Aren't Listening

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Testosterone and doping control

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Gym and tonic: a profile of 100 male steroid users

21 January 2018

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Skeletal muscle morphology in power-lifters with and without anabolic steroids

21 January 2018

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Effects of androgenic-anabolic steroids in athletes

21 January 2018

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Proof of the effect of testosterone on skeletal muscle

21 January 2018

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Drug testing at the 10th Asian Games and 24th Seoul Olympic Games.

21 January 2018

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Psychiatric and medical effects of anabolic-androgenic steroid use. A controlled study of 160 athletes.

21 January 2018

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Abuse of supraphysiologic doses of anabolic steroids

21 January 2018

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Effects of androgens on haemostasis

21 January 2018

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Effects of graded doses of testosterone on erythropoiesis in healthy young and older men.

21 January 2018

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Psychosexual effects of three doses of testosterone cycling in normal men.

21 January 2018

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Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial

21 January 2018

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Should pharmacogenomic studies be required for new drug approval?

21 January 2018

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The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

21 January 2018

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Quantitating genetic and nongenetic factors influencing androgen production and clearance rates in men.

21 January 2018

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Phenotypic heterogeneity of mutations in androgen receptor gene

21 January 2018

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Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men.

21 January 2018

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Age, genetic, and nongenetic factors influencing variation in serum sex steroids and zonal volumes of the prostate and benign prostatic hyperplasia in twins.

21 January 2018

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Heritability of plasma sex hormones and hormone binding globulin in adult male twins

21 January 2018

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Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort

21 January 2018

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Polymorphisms associated with circulating sex hormone levels in postmenopausal women

21 January 2018

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SHBGGene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone Mineral Density

21 January 2018

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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

The mechanism of the synthesis of 16-androstenes in human testicular homogenates

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes

21 January 2018

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Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family

21 January 2018

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Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity

21 January 2018

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Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues

21 January 2018

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Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review

21 January 2018

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Genetic variation of 3 beta-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: implications for prostate cancer risk

21 January 2018

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Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk

21 January 2018

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Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase

21 January 2018

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17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells

21 January 2018

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Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women

21 January 2018

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The role of 17 beta-hydroxysteroid dehydrogenases.

21 January 2018

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Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3

21 January 2018

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Association of the G289S single nucleotide polymorphism in the HSD17B3 gene with prostate cancer in Italian men.

21 January 2018

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A new nomenclature for the aldo-keto reductase superfamily

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women

21 January 2018

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Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues

21 January 2018

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A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

The aldo-keto reductase (AKR) superfamily: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1

21 January 2018

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Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia.

21 January 2018

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CYP7B generates a selective estrogen receptor beta agonist in human prostate

21 January 2018

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Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

A role for estrogen receptor beta in the regulation of growth of the ventral prostate

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians

21 January 2018

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Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma

21 January 2018

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Androgen abuse by athletes

21 January 2018

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A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort

21 January 2018

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Human aromatase: gene resequencing and functional genomics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study

21 January 2018

1 reference

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Inhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Isolation and quantification by high-performance liquid chromatography-ion-trap mass spectrometry of androgen sulfoconjugates in human urine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

21 January 2018

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Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene

21 January 2018

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Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: Frequency of DD homozygotes increases with Gleason Score

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

A human minor histocompatibility antigen resulting from differential expression due to a gene deletion

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Bayesian detection of abnormal values in longitudinal biomarkers with an application to T/E ratio.

21 January 2018

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Substantial advantage of a combined Bayesian and genotyping approach in testosterone doping tests

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men.

21 January 2018

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Genetic diversity and new therapeutic concepts

21 January 2018

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Left ventricular size and function in elite bodybuilders using anabolic steroids.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

Anabolic-androgenic steroid use among 133 prisoners

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902976862

The Uridine Diphosphate Glucuronosyltransferase 2B15 D85Y and 2B17 Deletion Polymorphisms Predict the Glucuronidation Pattern of Androgens and Fat Mass in Men

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Violence Toward Women and Illicit Androgenic-Anabolic Steroid Use

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

Testosterone therapy in the aging male

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902976862

10.1517/17425250902976862

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference