Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases (Q37486142)

20 August 2017

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title

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases (English)

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20 August 2017

Jin-Tang Dong

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Ceshi Chen

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20 August 2017

publication date

16 May 2009

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Cellular and Molecular Life Sciences

20 August 2017

published in

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20 August 2017

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20 August 2017

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20 August 2017

page(s)

2691-2706

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Deletion, mutation, and loss of expression of KLF6 in human prostate cancer

20 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Transcriptional activation domain of human BTEB2, a GC box-binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

DNA copy number losses in human neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Regulation of MAO-A and MAO-B gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0045-Z

Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation

21 January 2018

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12 December 2020

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

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12 December 2020

Gene structure and promoter analysis of the rat BTEB2 gene

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12 December 2020

Transcriptional regulation of smooth muscle phenotypic modulation.

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12 December 2020

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

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12 December 2020

cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2

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12 December 2020

Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer.

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12 December 2020

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

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12 December 2020

Expression of Krüppel-like factor 5 in human gastric carcinomas

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12 December 2020

Mammalian Krüppel-like transcription factors: more than just a pretty finger

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12 December 2020

KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells.

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12 December 2020

Reprogramming of human somatic cells to pluripotency with defined factors

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12 December 2020

Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation.

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12 December 2020

KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1.

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12 December 2020

A core Klf circuitry regulates self-renewal of embryonic stem cells.

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12 December 2020

The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.

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12 December 2020

A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells

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12 December 2020

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

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12 December 2020

Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells

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12 December 2020

Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase

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12 December 2020

Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer

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12 December 2020

Helicobacter pylori infection induced alteration of gene expression in human gastric cells.

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12 December 2020

Intestinal tumor progression is associated with altered function of KLF5

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12 December 2020

Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles

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12 December 2020

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression

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12 December 2020

Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells.

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12 December 2020

Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification

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12 December 2020

Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface.

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12 December 2020

Three distinct regions of allelic loss at 13q14, 13q21-22, and 13q33 in prostate cancer

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12 December 2020

Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells

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12 December 2020

Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain

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12 December 2020

Generation of germline-competent induced pluripotent stem cells

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12 December 2020

Regulation of SRF/CArG-dependent gene transcription during chronic partial obstruction of murine small intestine

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12 December 2020

Identification of Wnt responsive genes using a murine mammary epithelial cell line model system

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12 December 2020

Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines

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12 December 2020

Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells

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12 December 2020

Regulation of human monoamine oxidase B gene by Sp1 and Sp3.

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12 December 2020

Phenotypic modulation of vascular smooth muscle cells: dissection of transcriptional regulatory mechanisms

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12 December 2020

Binding of factor VIIa to tissue factor on keratinocytes induces gene expression

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12 December 2020

Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain

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12 December 2020

KLF6, a candidate tumor suppressor gene mutated in prostate cancer

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12 December 2020

Capturing and profiling adult hair follicle stem cells.

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12 December 2020

Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal

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12 December 2020

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

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12 December 2020

Mammalian SP/KLF transcription factors: bring in the family

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12 December 2020

Transcriptional regulation of vascular smooth muscle cell phenotype

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12 December 2020

Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis

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12 December 2020

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology

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12 December 2020

Early growth-response factor 1 and basic transcriptional element-binding protein 2 expression in cardiac allografts

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12 December 2020

Transcriptional regulation by the Sp family proteins.

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12 December 2020

Mouse lactoferrin gene. Promoter-specific regulation by EGF and cDNA cloning of the EGF-response-element binding protein.

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12 December 2020

Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene

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12 December 2020

Vascular implications of the Krüppel-like family of transcription factors

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12 December 2020

Krüppel-like factors: three fingers in many pies

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12 December 2020

KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer

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12 December 2020

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

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12 December 2020

Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis

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12 December 2020

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

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12 December 2020

The two faces of transforming growth factor beta in carcinogenesis

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12 December 2020

Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells

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12 December 2020

Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma

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12 December 2020

Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture

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12 December 2020

Inhibition of monocyte chemoattractant protein-1 by Krüppel-like factor 5 small interfering RNA in the tumor necrosis factor- alpha-activated human umbilical vein endothelial cells

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12 December 2020

Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.

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12 December 2020

Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

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12 December 2020

KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia

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12 December 2020

SUMOylation regulates nuclear localization of Krüppel-like factor 5.

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12 December 2020

Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.

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12 December 2020

Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway

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12 December 2020

Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China

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12 December 2020

A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element

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12 December 2020

Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.

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12 December 2020

Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells

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12 December 2020

Kruppel-like factor 5 is required for perinatal lung morphogenesis and function

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12 December 2020

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia

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12 December 2020

Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells

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12 December 2020

Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

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12 December 2020

Deletion at 13q21 is associated with aggressive prostate cancers

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12 December 2020

Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs

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12 December 2020

Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene

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12 December 2020

Regulation of angiotensin II-Induced Krüppel-like factor 5 expression in vascular smooth muscle cells

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12 December 2020

All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5

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12 December 2020

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

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12 December 2020

The amplified WWP1 gene is a potential molecular target in breast cancer

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12 December 2020

Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: Potential relevance to vein graft hyperplasia.

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12 December 2020

Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer

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12 December 2020

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

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12 December 2020

Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

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12 December 2020

Defining a common region of deletion at 13q21 in human cancers

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12 December 2020

Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB

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12 December 2020

Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha

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12 December 2020

Sp1- and Krüppel-like transcription factors

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12 December 2020

Microarray analysis to identify molecular mechanisms of radiation-induced microvascular damage in normal tissues

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12 December 2020

Inducible expression of basic transcription factor-binding protein 2 (BTEB2), a member of zinc finger family of transcription factors, in cardiac allograft vascular disease

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12 December 2020

Significance of the transcription factor KLF5 in cardiovascular remodeling

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12 December 2020

Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5.

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12 December 2020

Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter

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12 December 2020

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines

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12 December 2020

Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

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12 December 2020

Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells

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12 December 2020

Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis

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12 December 2020

Tcf3 governs stem cell features and represses cell fate determination in skin

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12 December 2020

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection

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12 December 2020

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta

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12 December 2020

Low-level arsenite activates the transcription of genes involved in adipose differentiation

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12 December 2020

TGFbeta signaling in growth control, cancer, and heritable disorders

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12 December 2020

Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation

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12 December 2020

KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization

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12 December 2020

Functional interaction between the transcription factor Krüppel-like factor 5 and poly(ADP-ribose) polymerase-1 in cardiovascular apoptosis.

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12 December 2020

The biology of the mammalian Krüppel-like family of transcription factors

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12 December 2020

Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function

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12 December 2020

Epithelial stem cells: turning over new leaves

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12 December 2020

A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer

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12 December 2020

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle

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12 December 2020

Klf5 is involved in self-renewal of mouse embryonic stem cells

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12 December 2020

Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis

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12 December 2020

Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2.

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12 December 2020

Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras

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12 December 2020

KLF5/BTEB2, a Krüppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.

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12 December 2020

Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5

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12 December 2020

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening

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12 December 2020

KLF8 transcription factor participates in oncogenic transformation

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12 December 2020

Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells

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12 December 2020

Chromosomal gains and losses indicate oncogene and tumor suppressor gene candidates in salivary gland tumors

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12 December 2020

Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.

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12 December 2020

Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.

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12 December 2020

Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells

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12 December 2020

Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

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12 December 2020

Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses

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12 December 2020

Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia

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12 December 2020

KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line

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12 December 2020

10.1007/S00018-009-0045-Z

Identifiers

DOI

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20 August 2017

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