A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93. (Q37431320)

20 August 2017

A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93. (English)

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20 August 2017

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20 August 2017

Mark T Orr

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Steven G Reed

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20 August 2017

Rhea N Coler

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20 August 2017

Elyse A Beebe

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20 August 2017

Thomas E Hudson

series ordinal

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20 August 2017

James J Moon

series ordinal

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20 August 2017

language of work or name

English

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publication date

3 January 2014

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20 August 2017

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20 August 2017

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20 August 2017

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20 August 2017

e83884

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Creative Commons Attribution 4.0 International

20 August 2017

start time

3 January 2014

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

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MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

23 August 2017

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The next 10 years for tuberculosis vaccines: do we have the right plans in place?

23 August 2017

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Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation

23 August 2017

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Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica

23 August 2017

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Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment

23 August 2017

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Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants

23 August 2017

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The importance of adjuvant formulation in the development of a tuberculosis vaccine

23 August 2017

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Tuberculosis vaccines in clinical trials

23 August 2017

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Innate Immune Recognition ofMycobacterium tuberculosis

23 August 2017

1 reference

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Programming the magnitude and persistence of antibody responses with innate immunity

23 August 2017

1 reference

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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Use of defined TLR ligands as adjuvants within human vaccines.

23 August 2017

1 reference

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A synthetic adjuvant to enhance and expand immune responses to influenza vaccines

23 August 2017

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A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis

23 August 2017

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Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis.

23 August 2017

1 reference

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Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

23 August 2017

1 reference

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Clinical update of the AS04-adjuvanted human papillomavirus-16/18 cervical cancer vaccine, Cervarix

23 August 2017

1 reference

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Modulation of adaptive immunity with Toll-like receptors

23 August 2017

1 reference

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Tracking epitope-specific T cells.

23 August 2017

1 reference

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Cell-mediated immune responses in tuberculosis

23 August 2017

1 reference

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Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis

23 August 2017

1 reference

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Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Collaboration between the innate immune receptors dectin-1, TLRs, and Nods.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Cooperation of Toll-like receptor signals in innate immune defence

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

23 August 2017

1 reference

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The success and failure of BCG - implications for a novel tuberculosis vaccine

23 August 2017

1 reference

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Dual stimulation of MyD88-dependent Toll-like receptors induces synergistically enhanced production of inflammatory cytokines in murine bone marrow-derived dendritic cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3880254

The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells

2 September 2018

1 reference

12 December 2020

Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

1 reference

12 December 2020

Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy

1 reference

12 December 2020

Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0083884

Identifiers

DOI

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20 August 2017

0 references

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20 August 2017

PubMed publication ID

24404140

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