The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1 (Q37422654)

20 August 2017

The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1 (English)

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20 August 2017

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Veronique Vreys

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Robert Z Orlowski

object named as

Robert Z Orlowski

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20 August 2017

Alan T Remaley

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20 August 2017

Richard J Jones

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20 August 2017

Dongmin Gu

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20 August 2017

Chad C Bjorklund

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20 August 2017

Isere Kuiatse

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20 August 2017

Tarig Bashir

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20 August 2017

language of work or name

English

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publication date

2 July 2013

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Journal of Pharmacology and Experimental Therapeutics

20 August 2017

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20 August 2017

346

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20 August 2017

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20 August 2017

381-392

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describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3876782/fullTextXML

inferred from PubMed Central ID database lookup

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23 August 2017

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23 August 2017

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23 August 2017

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Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study

23 August 2017

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DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis

23 August 2017

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23 August 2017

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23 August 2017

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

23 August 2017

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Importance of different pathways of cellular cholesterol efflux

23 August 2017

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Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma

23 August 2017

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23 August 2017

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23 August 2017

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Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts.

23 August 2017

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Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells.

6 September 2017

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6 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease

14 September 2017

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Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.

14 September 2017

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14 September 2017

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Mdm2 and Mdm4 loss regulates distinct p53 activities

28 September 2017

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Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma.

28 September 2017

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Cholesterol levels in patients with multiple myeloma

26 June 2018

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Reduced low-density-lipoprotein cholesterol causing low serum cholesterol levels in gastrointestinal cancer: a case control study

11 August 2018

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ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

11 August 2018

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Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis

11 August 2018

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Cellular localization and trafficking of the human ABCA1 transporter

11 August 2018

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Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia

11 August 2018

1 reference

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Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells.

11 August 2018

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Apolipoprotein-mediated cellular cholesterol/phospholipid efflux and plasma high density lipoprotein level in mice

11 August 2018

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12 December 2020

A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors

1 reference

12 December 2020

Staining of cholesterol with the fluorescent antibiotic "filipin"

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12 December 2020

Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: evidence from studies in patients with leukaemia

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12 December 2020

Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease

1 reference

12 December 2020

Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis

1 reference

12 December 2020

Low levels of serum cholesterol/phospholipids are associated with the antiphospholipid antibodies in monoclonal gammopathy

1 reference

12 December 2020

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

1 reference

12 December 2020

Identifiers

DOI

10.1124/JPET.113.204958

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

23820125

1 reference