SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin (Q37417126)

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scientific article published on 16 August 2004

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English	SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin	scientific article published on 16 August 2004

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

based on heuristic

inferred from title

author name string

Chaojun Duan

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Minghua Li

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Liangyou Rui

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

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publication date

16 August 2004

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Europe PubMed Central

PMC publication ID

20 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

20 August 2017

279

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

42

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

43684-43691

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

1 reference

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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

1 reference

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Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways

1 reference

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Essential role of STAT3 in body weight and glucose homeostasis

1 reference

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

1 reference

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

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IRS proteins and the common path to diabetes

1 reference

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A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding

1 reference

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Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2

1 reference

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Intracellular signalling. Key enzyme in leptin-induced anorexia

1 reference

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Selective deletion of leptin receptor in neurons leads to obesity

1 reference

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Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis

1 reference

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1 reference

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SH2-B and APS are multimeric adapters that augment TrkA signaling

1 reference

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SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

1 reference

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Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta

1 reference

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Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

1 reference

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Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

1 reference

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The IRS-signalling system: a network of docking proteins that mediate insulin action

1 reference

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Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1 reference

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

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Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

1 reference

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6 September 2017

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1 reference

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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Abnormal splicing of the leptin receptor in diabetic mice

1 reference

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

1 reference

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Identification and expression cloning of a leptin receptor, OB-R

1 reference

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Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model

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Positional cloning of the mouse obese gene and its human homologue

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Identification of four chromosomal loci determining obesity in a multifactorial mouse model

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Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

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Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

1 reference

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Activation of downstream signals by the long form of the leptin receptor

1 reference

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

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1 reference

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1 reference

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Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity

1 reference

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Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.

1 reference

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1 reference

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1 reference

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

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IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15316008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15316008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15316008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M408495200

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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