Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia (Q37394992)

20 August 2017

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia (English)

1 reference

20 August 2017

1 reference

Xiang Xue

0 references

Stefano Rivella

0 references

Erik R Anderson

1 reference

20 August 2017

Matthew Taylor

1 reference

20 August 2017

Sadeesh K Ramakrishnan

1 reference

20 August 2017

Angelical Martin

1 reference

20 August 2017

Liwei Xie

1 reference

20 August 2017

Bryce X Bredell

1 reference

20 August 2017

Sara Gardenghi

1 reference

20 August 2017

Yatrik M Shah

1 reference

20 August 2017

language of work or name

English

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publication date

26 November 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

20 August 2017

1 reference

20 August 2017

110

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20 August 2017

1 reference

20 August 2017

E4922-30

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Iron homeostasis in the liver

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Molecular basis of iron-loading disorders.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

The treatment of secondary hemochromatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Small molecule inhibitors of divalent metal transporter-1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Regulation of iron absorption in hemoglobinopathies.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Animal models with enhanced erythropoiesis and iron absorption

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Iron Imports. II. Iron uptake at the apical membrane in the intestine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

An iron-regulated ferric reductase associated with the absorption of dietary iron

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

A mouse model for beta 0-thalassemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Liver iron concentrations and urinary hepcidin in beta-thalassemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Transferrin therapy ameliorates disease in beta-thalassemic mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

Microanalysis of non-heme iron in animal tissues

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864280

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1314197110

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1314197110

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

21 January 2018

1 reference

12 December 2020

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

12 December 2020

The Measurement of Iron Absorption by the Double Isotope Technique

1 reference

12 December 2020

Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1314197110

1 reference

release_zs4fvdei3bdippoj6prbcrrrby

20 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zs4fvdei3bdippoj6prbcrrrby

24 November 2022

mapped directly with Wikidata item

1 reference

20 August 2017

PubMed publication ID

24282296

1 reference