Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation (Q37351215)

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scientific article published on 15 December 2008

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English	Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation	scientific article published on 15 December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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1 reference

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inferred from title

5

object named as

James K Liao

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Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Ping-Yen Liu

1

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Europe PubMed Central

PMC publication ID

19 August 2017

Yen-Wen Liu

2

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Europe PubMed Central

PMC publication ID

19 August 2017

Li-Jen Lin

3

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Europe PubMed Central

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19 August 2017

Jyh-Hong Chen

4

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Europe PubMed Central

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19 August 2017

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publication date

15 December 2008

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Europe PubMed Central

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19 August 2017

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Europe PubMed Central

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19 August 2017

119

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Europe PubMed Central

PMC publication ID

19 August 2017

1

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Europe PubMed Central

PMC publication ID

19 August 2017

131-138

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Europe PubMed Central

PMC publication ID

19 August 2017

Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice

1 reference

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6 September 2017

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Simvastatin with or without ezetimibe in familial hypercholesterolemia

1 reference

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6 September 2017

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Increased Rho kinase activity in a Taiwanese population with metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Clinical implications for statin pleiotropy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

ROCKs as therapeutic targets in cardiovascular diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Intensive versus moderate lipid lowering with statins after acute coronary syndromes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Isoprenoids as mediators of the biological effects of statins

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MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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6 September 2017

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

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6 September 2017

Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

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6 September 2017

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1 reference

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6 September 2017

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

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6 September 2017

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

1 reference

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6 September 2017

The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

1 reference

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6 September 2017

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

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6 September 2017

Evaluation of methods for the measurement of low-density lipoprotein cholesterol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

6 September 2017

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

14 September 2017

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

28 September 2017

Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

26 June 2018

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

26 June 2018

Cholesterol lowering is more important than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

A method for measuring Rho kinase activity in tissues and cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive protein (<2 mg/L) and low-density lipoprotein cholesterol (< 70 mg/dl) targets in patients with type 2 diabetes mellitus (from the ANDROMEDA st

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2 September 2018

Treatment with ezetimibe plus low-dose atorvastatin compared with higher-dose atorvastatin alone: is sufficient cholesterol-lowering enough to inhibit platelets?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

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Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial

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2 September 2018

Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

C-reactive protein levels and outcomes after statin therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

Effect of coadministration of ezetimibe and simvastatin on high-sensitivity C-reactive protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745913

2 September 2018

Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin

1 reference

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2 September 2018

Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial

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2 September 2018

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

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Inhibition of intestinal cholesterol absorption by ezetimibe in humans

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2 September 2018

Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia

1 reference

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2 September 2018

Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering

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2 September 2018

HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells

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12 December 2020

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Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/19075102

12 December 2020

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Measurement of endothelial function by brachial artery flow-mediated vasodilation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19075102

12 December 2020

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Technical aspects of evaluating brachial artery vasodilatation using high-frequency ultrasound

1 reference

https://pubmed.ncbi.nlm.nih.gov/19075102

12 December 2020

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Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for ‘pleiotropic’ functions of statin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19075102

12 December 2020

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Identifiers

10.1161/CIRCULATIONAHA.108.813311

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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