A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain (Q37331417)

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scientific article published on 10 April 2009

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English	A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain	scientific article published on 10 April 2009

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25 January 2020

A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain (English)

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25 January 2020

Alzheimer's disease

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based on heuristic

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Camille Broadwater-Hollifield

6

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25 January 2020

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Floyd Sarsoza

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Tommy Saing

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Rakez Kayed

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Robert Dahlin

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Malcolm Dick

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Scott Mobley

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Ira Lott

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Eric Doran

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Daniel Gillen

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Clifford Anderson-Bergman

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David H Cribbs

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Charles Glabe

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Elizabeth Head

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10 April 2009

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25 January 2020

Acta Neuropathologica

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25 January 2020

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25 January 2020

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25 January 2020

505-517

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25 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2737113/fullTextXML

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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6 September 2017

Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

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6 September 2017

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

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A guided tour into subcellular colocalization analysis in light microscopy

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6 September 2017

A specific amyloid-beta protein assembly in the brain impairs memory

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6 September 2017

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

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6 September 2017

Structural properties of Abeta protofibrils stabilized by a small molecule.

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6 September 2017

Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

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6 September 2017

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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6 September 2017

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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6 September 2017

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

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6 September 2017

Down syndrome and Alzheimer's disease: a link between development and aging

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6 September 2017

Mild cognitive impairment represents early-stage Alzheimer disease

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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6 September 2017

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

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6 September 2017

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Mild cognitive impairment: clinical characterization and outcome

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6 September 2017

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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Plaques and tangles: searching for primary events in a forest of data.

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The pathogenesis of senile plaques

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Staging of Alzheimer-related cortical destruction

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The pathological association between Down syndrome and Alzheimer disease

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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6 September 2017

Simultaneous demonstration of multiple antigens by indirect immunofluorescence or immunogold staining. Novel light and electron microscopical double and triple staining method employing primary antibodies from the same species

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6 September 2017

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease

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6 September 2017

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

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Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Neuropathological stageing of Alzheimer-related changes

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Precocious aging and dementia in patients with Down's syndrome

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Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

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Do beta-amyloid (Abeta) deposits in patients with Alzheimer's disease and Down's syndrome grow according to the log-normal model?

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26 June 2018

Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease

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26 June 2018

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

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26 June 2018

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

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26 June 2018

Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging.

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26 June 2018

Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease

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26 June 2018

Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

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26 June 2018

Correlations of synaptic and pathological markers with cognition of the elderly

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26 June 2018

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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26 June 2018

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26 June 2018

The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy.

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Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease.

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26 June 2018

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

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26 June 2018

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

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A prospective study of Alzheimer disease in Down syndrome.

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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26 June 2018

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2 September 2018

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome

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2 September 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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2 September 2018

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2 September 2018

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease

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2 September 2018

Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis

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2 September 2018

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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2 September 2018

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

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2 September 2018

Behavioural disturbance in people with Down's syndrome and dementia.

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2 September 2018

Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease.

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2 September 2018

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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2 September 2018

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease

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based on heuristic

inferred from PubMed ID database lookup

Diagnosis of Alzheimer's disease

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19360426

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs

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based on heuristic

inferred from PubMed ID database lookup

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

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https://pubmed.ncbi.nlm.nih.gov/19360426

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00401-009-0530-3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19360426%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19360426%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19360426%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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