Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine (Q37309244)

19 August 2017

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title

Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine (English)

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19 August 2017

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Robert Thimme

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19 August 2017

Christoph Neumann-Haefelin

series ordinal

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19 August 2017

Tobias Boettler

series ordinal

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19 August 2017

Hubert E Blum

series ordinal

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19 August 2017

publication date

1 May 2008

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19 August 2017

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19 August 2017

volume

389

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19 August 2017

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19 August 2017

page(s)

457-467

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Prospective study of viral clearance and CD4(+) T-cell response in acute hepatitis C primary infection and reinfection.

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

The natural history of hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Restoring function in exhausted CD8 T cells during chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

In vitro assay for neutralizing antibody to hepatitis C virus: Evidence for broadly conserved neutralization epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

IL-10, T cell exhaustion and viral persistence

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Analysis of a successful immune response against hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Cellular immune selection with hepatitis C virus persistence in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Resolution of a chronic viral infection after interleukin-10 receptor blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Prospects for a vaccine against the hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Analysis of successful immune responses in persons infected with hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Neutralizing antibody response during acute and chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Presence of functional dendritic cells in patients chronically infected with hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Previously Infected and Recovered Chimpanzees Exhibit Rapid Responses That Control Hepatitis C Virus Replication upon Rechallenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Protection against persistence of hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Humoral immune response in acute hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: functional characterization in patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Divergent and convergent evolution after a common-source outbreak of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Relation between viral fitness and immune escape within the hepatitis C virus protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Immune evasion versus recovery after acute hepatitis C virus infection from a shared source

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Determinants of viral clearance and persistence during acute hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

A target on the move: innate and adaptive immune escape strategies of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

CD8 Epitope Escape and Reversion in Acute HCV Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Virus-Specific CD8+ Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Detection of Diverse Hepatitis C Virus (HCV)-Specific Cytotoxic T Lymphocytes in Peripheral Blood of Infected Persons by Screening for Responses to All Translated Proteins of HCV

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Host genetic determinants in hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.061

21 January 2018

Identifiers

DOI

10.1515/BC.2008.061

1 reference

19 August 2017

1 reference