Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues (Q37307990)

19 August 2017

Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues (English)

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19 August 2017

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Hayato Ishikawa

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19 August 2017

David A Colby

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19 August 2017

Shigeki Seto

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19 August 2017

Porino Va

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19 August 2017

Annie Tam

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19 August 2017

Hiroyuki Kakei

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19 August 2017

Thomas J Rayl

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19 August 2017

Inkyu Hwang

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19 August 2017

Dale L Boger

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19 August 2017

language of work or name

English

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publication date

1 April 2009

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Journal of the American Chemical Society

19 August 2017

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19 August 2017

131

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19 August 2017

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19 August 2017

4904-4916

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Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Total synthesis of (-)- and ent-(+)-vindoline

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Stereocontrolled total synthesis of (+)-vincristine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

The Catharanthus alkaloids: pharmacognosy and biotechnology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Novel aspects of natural and modified vinca alkaloids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Anticancer therapy with novel tubulin-interacting drugs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Modifications in the "upper" velbenamine part of the Vinca alkaloids have major implications for tubulin interacting activities

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Structures of leurocristine (vincristine) and vincaleukoblastine. X-ray analysis of leurocristine methiodide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Syntheses and biological evaluation of vinblastine congeners

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Total synthesis of indole and dihydroindole alkaloids. IX. Studies on the synthesis of bisindole alkaloids in the vinblastine-vincristine series. The biogenetic approach

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

N-Deformyl Vincristine a Bisalkaloid from Catharanthus roseus

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Stereocontrolled total synthesis of (+)-vinblastine

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Vinca alkaloids: anti-vascular effects in a murine tumour

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727944

Application of a modification of the Polonovski reaction to the synthesis of vinblastine-type alkaloids

2 September 2018

1 reference

12 December 2020

Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles

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12 December 2020

A note on the alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.). II. Catharanthine, lochnericine, vindolinine, and vindoline

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12 December 2020

Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts

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12 December 2020

ALKALOIDS OF VINCA ROSEA LINN. (CATHARANTHUS ROSEUS G. DON). XXIV. VINASPINE, VINCATHICINE, ROVIDINE, DESACETYL VLB, AND VINAPHAMINE

1 reference

12 December 2020

Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the synthesis of bisindole alkaloids in the vinblastine‐vincristine series. The chloroindolenine approach

1 reference

12 December 2020

Synthesis of (+)-vinblastine and its analogues

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12 December 2020

Co(III)-alkyl complex- and Co(III)-alkylperoxo complex-catalyzed triethylsilylperoxidation of alkenes with molecular oxygen and triethylsilane

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12 December 2020

Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.). V. Preparation and characterization of alkaloids

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12 December 2020

Role of chance observations in chemotherapy: Vinca rosea

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12 December 2020

Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetyl vinblastine amide (vindesine) sulfate

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12 December 2020

Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don). 38. 4'-Dehydrated derivatives

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12 December 2020

Antiangiogenesis is produced by nontoxic doses of vinblastine

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12 December 2020

Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism

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12 December 2020

Termination of Mn(III)-based oxidative cyclizations by trapping with azide

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12 December 2020

Preclinical studies with vinglycinate, one of a series of chemically derived analogs of vinblastine

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12 December 2020

Vinca alkaloids XXXV. Desacetoxyvinblastine a new minor alkaloid fromVinca rosea L. (Catharanthus roseus G. Don)

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12 December 2020

Identifiers

DOI

10.1021/JA809842B

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19 August 2017

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19 August 2017

PubMed publication ID

19292450

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