Relevance of transgenic mouse models to human Alzheimer disease (Q37307236)

19 August 2017

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title

Relevance of transgenic mouse models to human Alzheimer disease (English)

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19 August 2017

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Debbi A Morrissette

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19 August 2017

Anna Parachikova

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19 August 2017

Kim N Green

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19 August 2017

Frank M LaFerla

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19 August 2017

language of work or name

English

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publication date

22 October 2008

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Journal of Biological Chemistry

19 August 2017

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inferred from page(s)

published in

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19 August 2017

volume

284

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19 August 2017

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19 August 2017

page(s)

6033-6037

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The gamma-secretase complex: membrane-embedded proteolytic ensemble

19 August 2017

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

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Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

21 January 2018

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21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

21 January 2018

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A decade of tau transgenic animal models and beyond

21 January 2018

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Pathways by which Abeta facilitates tau pathology

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21 January 2018

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Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2

21 January 2018

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

21 January 2018

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Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

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Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction

21 January 2018

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Alzheimer's disease is a synaptic failure

21 January 2018

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APP processing and synaptic function

21 January 2018

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21 January 2018

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Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

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Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

21 January 2018

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Modulation of cell death by mouse genotype: differential vulnerability to excitatory amino acid-induced lesions

21 January 2018

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Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouse

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.R800030200

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19 August 2017

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