Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin (Q37287003)

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scientific article published on 16 June 2008

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English	Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin	scientific article published on 16 June 2008

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

LDL cholesterol

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based on heuristic

inferred from title

alternative mRNA splicing, via spliceosome

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Jerome I Rotter

4

object named as

Jerome I Rotter

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Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Marisa Wong Medina

1

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Europe PubMed Central

PMC publication ID

19 August 2017

Feng Gao

2

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Europe PubMed Central

PMC publication ID

19 August 2017

Weiming Ruan

3

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Europe PubMed Central

PMC publication ID

19 August 2017

Ronald M Krauss

5

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Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

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publication date

16 June 2008

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Europe PubMed Central

PMC publication ID

19 August 2017

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Europe PubMed Central

PMC publication ID

19 August 2017

118

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Europe PubMed Central

PMC publication ID

19 August 2017

4

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Europe PubMed Central

PMC publication ID

19 August 2017

355-362

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Europe PubMed Central

PMC publication ID

19 August 2017

A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Validation of using gene expression in mononuclear cells as a marker for hepatic cholesterol metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

The relevance of alternative RNA splicing to pharmacogenomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Statins, super-statins and cholesterol absorption inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

1 reference

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6 September 2017

Structural mechanism for statin inhibition of HMG-CoA reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Genomic structure of the gene encoding human 3-hydroxy-3-methyl-glutaryl coenzyme A reductase: comparison of exon/intron organization of sterol-sensing domains among four related genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

6 September 2017

Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

28 September 2017

Regulation of cholesterol metabolism in the ethionine-induced premalignant rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

26 June 2018

Epstein-Barr virus transformation of cryopreserved lymphocytes: prolonged experience with technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

26 June 2018

Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. Effect of patient characteristics on lovastatin-induced changes in plasma concentrations of lipids and lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

26 June 2018

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Pharmacogenetic study of statin therapy and cholesterol reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

The role of a common TNNT2 polymorphism in cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West Of Scotland Coronary Prevention Study (WOSCOPS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Relationship between plasma LDL concentrations during treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Use of cyclosporin A in establishing Epstein-Barr virus-transformed human lymphoblastoid cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720070

3 September 2018

Separation of White Blood Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins and risk of coronary heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Association of GNB3 gene C825T polymorphism with coronary heart disease]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCULATIONAHA.108.773267

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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