RAS: target for cancer therapy (Q37271795)

19 August 2017

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title

RAS: target for cancer therapy (English)

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19 August 2017

Nandita Saxena

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19 August 2017

Sitanshu Sekhar Lahiri

series ordinal

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19 August 2017

Shashank Hambarde

series ordinal

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19 August 2017

Rajendra Prasad Tripathi

series ordinal

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19 August 2017

publication date

1 November 2008

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19 August 2017

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19 August 2017

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19 August 2017

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19 August 2017

page(s)

948-955

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https://api.crossref.org/works/10.1080%2F07357900802087275

19 August 2017

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Proteins regulating Ras and its relatives

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Function and regulation of ras.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

RAS oncogenes: the first 30 years.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Regulators and Effectors of ras Proteins

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Three human transforming genes are related to the viral ras oncogenes

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

21 January 2018

CaaX converting enzymes

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https://api.crossref.org/works/10.1080%2F07357900802087275

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Signaling interplay in Ras superfamily function

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

The tuberous sclerosis complex

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Ras and Rho regulation of the cell cycle and oncogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Phospholipase C(epsilon): a novel Ras effector

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Signaling through the epidermal growth factor receptor during the development of malignancy

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Lipid posttranslational modifications. Farnesyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900802087275

Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900802087275

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900802087275

Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Mutations of the BRAF gene in human cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

BRAF mutation predicts sensitivity to MEK inhibition

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900802087275

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900802087275

Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900802087275

10.1080/07357900802087275

21 January 2018

Identifiers

DOI

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19 August 2017

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