The continuing saga of the marine polyether biotoxins (Q37258530)

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13 January 2020

review article

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title

The continuing saga of the marine polyether biotoxins (English)

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13 January 2020

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13 January 2020

K C Nicolaou

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13 January 2020

Michael O Frederick

series ordinal

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13 January 2020

language of work or name

English

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publication date

1 January 2008

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Angewandte Chemie International Edition

13 January 2020

published in

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13 January 2020

volume

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13 January 2020

issue

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13 January 2020

page(s)

7182-7225

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Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

13 January 2020

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Recent advances in the synthesis of marine polycyclic ether natural products.

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Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin

6 September 2017

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On the structure of maitotoxin

6 September 2017

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Construction of fused polycyclic ethers by strategies involving ring-closing metathesis

6 September 2017

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Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin

6 September 2017

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Ladder polyether synthesis via epoxide-opening cascades using a disappearing directing group

6 September 2017

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6 September 2017

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Total synthesis of gambierol: the generation of the A-C and F-H subunits by using a C-glycoside centered strategy

6 September 2017

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A new polyether ladder compound produced by the dinoflagellate Karenia brevis

6 September 2017

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The total synthesis of gambierol

6 September 2017

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Evolution of a practical total synthesis of ciguatoxin CTX3C.

6 September 2017

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Total synthesis of brevetoxin-B

6 September 2017

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Airway responses to aerosolized brevetoxins in an animal model of asthma

6 September 2017

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Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays

6 September 2017

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First- and second-generation total synthesis of ciguatoxin CTX3C.

6 September 2017

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Stereoselective construction of cyclic ethers using a tandem two-component etherification: elucidation of the role of bismuth tribromide

6 September 2017

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Synthesis and biological evaluation of gambierol analogues

6 September 2017

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Desymmetrization of a centrosymmetric diepoxide: efficient synthesis of a key intermediate in a total synthesis of hemibrevetoxin B

6 September 2017

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New efficient iterative approaches to polycyclic ethers

6 September 2017

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Stereoselective convergent synthesis of a trans-fused polycyclic ether ring system including a 4-hydroxy-5-methyl-tetrahydropyran ring

6 September 2017

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The chemistry and biological function of natural marine toxins

6 September 2017

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Sequencing Reactions with Samarium(II) Iodide

6 September 2017

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Total synthesis of ciguatoxin CTX3C.

6 September 2017

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Formal Total Synthesis of Hemibrevetoxin B by an Oxiranyl Anion Strategy

6 September 2017

1 reference

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Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts

6 September 2017

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Total synthesis of brevetoxin A

6 September 2017

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Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis

6 September 2017

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6 September 2017

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Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate

6 September 2017

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Maitotoxin: a unique pharmacological tool for research on calcium-dependent mechanisms

6 September 2017

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6 September 2017

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Total synthesis, structure revision, and absolute configuration of (-)-brevenal

14 September 2017

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De novo asymmetric synthesis of D- and L-swainsonine

26 June 2018

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Total synthesis of (-)-gambierol

26 June 2018

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The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels

26 June 2018

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Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens

26 June 2018

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Maitotoxin, a Ca2+ channel activator candidate

26 June 2018

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Maitotoxin and Bay-K-8644: two putative calcium channel activators with different effects on endogenous dopamine release from tuberoinfundibular neurons

26 June 2018

1 reference

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Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes.

26 June 2018

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Pertussis toxin (IAP) enhances maitotoxin (a putative Ca2+ channel agonist)-induced Ca2+ entry into synaptosomes

26 June 2018

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Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown

26 June 2018

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Stereoselective total synthesis of methyl alpha-D and alpha-L-glucopyranosides

26 June 2018

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Selective stimulation of Ca2+ flux in cells by maitotoxin

26 June 2018

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Oceanography: red tide rising

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De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction

3 September 2018

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3 September 2018

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Total synthesis of the proposed structure of brevenal

3 September 2018

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3 September 2018

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Maitotoxin potently promotes Ca2+ influx in mouse spermatogenic cells and sperm, and induces the acrosome reaction.

3 September 2018

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Biomimetic synthesis of trans,syn,trans-fused polyoxepanes: remarkable substituent effects on the endo-regioselective oxacyclization of polyepoxides.

3 September 2018

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Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues.

3 September 2018

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A new stereoselective synthesis of ciguatoxin right wing fragments

3 September 2018

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Total synthesis of gymnocin-A.

3 September 2018

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Convergent Total Syntheses of Gambierol and 16-epi-Gambierol and Their Biological Activities

3 September 2018

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A convergent total synthesis of hemibrevetoxin B.

3 September 2018

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Synthesis-based approach toward direct sandwich immunoassay for ciguatoxin CTX3C.

3 September 2018

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Total synthesis of gambierol

3 September 2018

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Endo-oxacyclizations of polyepoxides: biomimetic synthesis of fused polycyclic ethers

3 September 2018

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Convergent synthesis of polycyclic ethers via the intramolecular allylation of alpha-acetoxy ethers and subsequent ring-closing metathesis

3 September 2018

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Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers

3 September 2018

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Maitotoxin-induced calcium influx in erythrocyte ghosts and rat glioma C6 cells, and blockade by gangliosides and other membrane lipids

3 September 2018

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Inhibition of Maitotoxin‐Induced Ca2+ Influx in Rat Glioma C6 Cells by Brevetoxins and Synthetic Fragments of Maitotoxin

3 September 2018

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Ciguatoxin is a novel type of Na+ channel toxin

3 September 2018

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Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues: Elucidation of Crucial Structural Elements for Potent Toxicity

3 September 2018

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Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells

3 December 2018

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12 December 2020

SiMe3-based homologation-epoxidation-cyclization strategy for ladder THP synthesis

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12 December 2020

Syntheses of four D- and L-hexoses via diastereoselective and enantioselective dihydroxylation reactions

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12 December 2020

Alkene substituents for selective activation of endo-regioselective polyepoxide oxacyclizations

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12 December 2020

Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis)

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12 December 2020

Toxin T4(6) from Ptychodiscus brevis (formerly Gymnodinium breve) enhances activation of voltage-sensitive sodium channels by veratridine

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12 December 2020

Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

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12 December 2020

Maitotoxin, a potent, general activator of phosphoinositide breakdown

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12 December 2020

Total synthesis of gambierol: subunit coupling and completion

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12 December 2020

Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels

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12 December 2020

Maitotoxin: effects on calcium channels, phosphoinositide breakdown, and arachidonate release in pheochromocytoma PC12 cells

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12 December 2020

Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A

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12 December 2020

A highly efficient synthesis of the hemibrevetoxin B ring system

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12 December 2020

Studies toward the Total Synthesis of Gymnocin A, a Cytotoxic Polyether: A Highly Convergent Entry to the F−N Ring Fragment

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12 December 2020

Synthetic Studies toward Gambierol. Convergent Synthesis of the Octacyclic Polyether Core

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12 December 2020

New synthetic technology for the construction of oxocenes

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12 December 2020

Stereochemical Determination of Acyclic Structures Based on Carbon-Proton Spin-Coupling Constants. A Method of Configuration Analysis for Natural Products

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12 December 2020

C-glycosides to fused polycyclic ethers. An efficient entry into the A-D ring system of gambierol

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12 December 2020

Synthesis of an F-H gambierol subunit using a C-glycoside-centered strategy

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12 December 2020

Concise synthesis of cyclic ethers via the palladium-catalyzed coupling of ketene acetal triflates and organozinc reagents. Application to the iterative synthesis of polycyclic ethers

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12 December 2020

Metathesis reactions in total synthesis

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12 December 2020

Practical total synthesis of ciguatoxin CTX3C by improved protective group strategy

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12 December 2020

The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article

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12 December 2020

Convergent synthesis of polycyclic ethers via the intramolecular allylation of alpha-acetoxy ethers and subsequent ring-closing metathesis: synthesis of the CDEFG ring system of gambierol

1 reference

12 December 2020

C-glycosides to fused polycyclic ethers. A formal synthesis of (+/-)-hemibrevetoxin B

1 reference

12 December 2020

Stereoselective syntheses of the C'D'E'F'-ring system of maitotoxin and the FG-ring system of gambierol

1 reference

12 December 2020

Synthesis of oxepanes and trans-fused bisoxepanes via biomimetic, endo-regioselective tandem oxacyclizations of polyepoxides

1 reference

12 December 2020

Highly functionalized pyranopyrans from furans: a synthesis of the C27-C38 and C44-C53 subunits of norhalichondrin B

1 reference

12 December 2020

Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral alpha-helix peptides

1 reference

12 December 2020

Synthesis of the spirastrellolide A trioxadispiroketal

1 reference

12 December 2020

Complete structure of maitotoxin

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC199870020339

Identifiers

DOI

10.1002/ANIE.200801696

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18763702%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18763702%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

18763702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18763702%20AND%20SRC:MED&resulttype=core&format=json