Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion (Q37236496)

19 August 2017

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion (English)

1 reference

19 August 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

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14 June 2020

author name string

Jocelyn E Manning Fox

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Kevin L Zhang

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

James D Johnson

series ordinal

1 reference

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14 June 2020

language of work or name

English

0 references

publication date

24 September 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 August 2017

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14 June 2020

volume

110

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14 June 2020

issue

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14 June 2020

page(s)

16480-16485

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describes a project that uses

14 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3799350/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.

6 September 2017

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6 September 2017

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Presenilin-dependent receptor processing is required for axon guidance

6 September 2017

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Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

6 September 2017

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Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition.

6 September 2017

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Moving away from the midline: new developments for Slit and Robo

6 September 2017

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Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion

6 September 2017

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Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways

6 September 2017

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Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells

6 September 2017

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Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets

6 September 2017

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Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse

6 September 2017

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Control of pancreatic beta-cell fate by insulin signaling: The sweet spot hypothesis

6 September 2017

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Insulin stimulates primary beta-cell proliferation via Raf-1 kinase

6 September 2017

1 reference

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Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.

6 September 2017

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Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells

6 September 2017

1 reference

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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

6 September 2017

1 reference

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Potential role of the Slit/Robo signal pathway in angiogenesis.

6 September 2017

1 reference

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Molecular mechanisms of axon guidance

6 September 2017

1 reference

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Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

6 September 2017

1 reference

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Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

6 September 2017

1 reference

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The actin cytoskeleton: a key regulator of apoptosis and ageing?

6 September 2017

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

6 September 2017

1 reference

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Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

6 September 2017

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Conserved roles for Slit and Robo proteins in midline commissural axon guidance

6 September 2017

1 reference

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Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration

6 September 2017

1 reference

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Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

6 September 2017

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Quantification of expression of netrins, slits and their receptors in human prostate tumors

6 September 2017

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Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

6 September 2017

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Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

6 September 2017

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The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

6 September 2017

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Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex

6 September 2017

1 reference

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Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

6 September 2017

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6 September 2017

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Pancreatic beta cells synthesize and secrete nerve growth factor

6 September 2017

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6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Maturation of adult beta-cells revealed using a Pdx1/insulin dual-reporter lentivirus.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Pituitary adenylate cyclase‐activating polypeptide (PACAP) is an islet substance serving as an intra‐islet amplifier Of glucose‐induced insulin secretion in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Immunohistochemical localization of hepatocyte growth factor protein in pancreas islet A-cells of man and rats

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Effect of actin cytoskeleton disruption on electric pulse-induced apoptosis and electroporation in tumour cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Reciprocal modulation of adult beta cell maturity by activin A and follistatin

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca2+ influx through L-type Ca2+ channels in beta-cells and localization in islets.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob/ obmice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799350

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24065825

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pro-Survival Role of Gelsolin in Mouse -Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24065825

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1214312110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

PubMed publication ID

24065825

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24065825%20AND%20SRC:MED&resulttype=core&format=json