Dual localization of wild-type myocilin in the endoplasmic reticulum and extracellular compartment likely occurs due to its incomplete secretion. (Q37126077)

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scientific article published on 13 March 2009

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English	Dual localization of wild-type myocilin in the endoplasmic reticulum and extracellular compartment likely occurs due to its incomplete secretion.	scientific article published on 13 March 2009

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scholarly article

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23 January 2020

Dual localization of wild-type myocilin in the endoplasmic reticulum and extracellular compartment likely occurs due to its incomplete secretion (English)

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23 January 2020

endoplasmic reticulum

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author name string

Seongsoo Sohn

1

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23 January 2020

Myung Kuk Joe

2

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23 January 2020

Tae Eun Kim

3

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23 January 2020

Ji-Eun Im

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23 January 2020

Young Ran Choi

5

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23 January 2020

Hwayong Park

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23 January 2020

Changwon Kee

7

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23 January 2020

publication date

13 March 2009

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23 January 2020

Molecular Vision

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23 January 2020

15

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23 January 2020

545-556

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23 January 2020

Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Cell death in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Bi-directional protein transport between the ER and Golgi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Genetic dissection of myocilin glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Myocilin glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Expression of wild-type and truncated myocilins in trabecular meshwork cells: their subcellular localizations and cytotoxicities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Optimedin: a novel olfactomedin-related protein that interacts with myocilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Immunofluorescence method for quantifying the trabecular meshwork glucocorticoid response (TIGR) protein in trabecular meshwork and Schlemm's canal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Identification of a gene that causes primary open angle glaucoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Number of people with glaucoma worldwide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Eicosanoid production and glucocorticoid regulatory mechanisms in cultured human trabecular meshwork cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

14 September 2017

Post-transcriptional modification of the gene genetically linked to juvenile open-angle glaucoma; novel transcripts in human ocular tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

29 September 2017

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

29 September 2017

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

29 September 2017

A cellular assay distinguishes normal and mutant TIGR/myocilin protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

29 September 2017

Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

27 June 2018

Extracellular trafficking of myocilin in human trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Overexpression of myocilin in cultured human trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654785

3 September 2018

Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inefficient processing of an olfactomedin-deficient myocilin mutant: potential physiological relevance to glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence and properties of myocilin in the aqueous humor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How can the products of a single gene be localized to more than one intracellular compartment?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TIGR/myocilin in human aqueous humor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New evidence of the substrate specificity of endo-beta-N-acetylglucosaminidase D

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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23 January 2020

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23 January 2020

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