Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases (Q37118507)

18 August 2017

1 reference

title

Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases (English)

1 reference

18 August 2017

1 reference

William L Scott

1 reference

PMC publication ID

2651689

18 August 2017

Martin J O'Donnell

series ordinal

1 reference

18 August 2017

1 January 2009

1 reference

ACS Combinatorial Science

18 August 2017

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

18 August 2017

3-13

1 reference

Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction.

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Application of combinatorial chemistry science on modern drug discovery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Natural products as sources of new drugs over the last 25 years

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Using grid techniques for drug target identification

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Innovative lead discovery strategies for tropical diseases

14 September 2017

1 reference

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Comprehensive survey of combinatorial library synthesis: 2005.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Can open-source R&D reinvigorate drug research?

14 September 2017

1 reference

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Patent nonsense: evidence tells of an industry out of social control

14 September 2017

1 reference

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

14 September 2017

1 reference

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The anti-intellectual effects of intellectual property

14 September 2017

1 reference

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Virtual ligand screening: strategies, perspectives and limitations

14 September 2017

1 reference

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Open computing grid for molecular science and engineering

14 September 2017

1 reference

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Expanding global research and development for neglected diseases

14 September 2017

1 reference

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Data sharing and intellectual property in a genomic epidemiology network: policies for large-scale research collaboration

14 September 2017

1 reference

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Challenges for chemoinformatics education in drug discovery

14 September 2017

1 reference

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Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures

14 September 2017

1 reference

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Comprehensive survey of combinatorial library synthesis: 2004.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Gates's grandest challenge: transcending technology as public health ideology

14 September 2017

1 reference

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Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

14 September 2017

1 reference

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The role of natural product chemistry in drug discovery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Navigating chemical space for biology and medicine

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Methods for library design and optimisation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Integration of virtual screening into the drug discovery process

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

NIH Molecular Libraries Initiative

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Solid-phase synthesis of an alkylaminobenzanilide library

14 September 2017

1 reference

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Comprehensive survey of combinatorial library synthesis: 2003.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

The global burden of chronic diseases: overcoming impediments to prevention and control

14 September 2017

1 reference

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Virtual drug discovery and development for neglected diseases through public-private partnerships

14 September 2017

1 reference

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Comprehensive Survey of Combinatorial Library Synthesis: 2002

14 September 2017

1 reference

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Public health. Grand Challenges in Global Health

14 September 2017

1 reference

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Quality control in combinatorial chemistry: determination of the quantity, purity, and quantitative purity of compounds in combinatorial libraries

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Diketopiperazines in peptide and combinatorial chemistry.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Grid technologies empowering drug discovery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

High-throughput bioassay-guided fractionation: a technique for rapidly assigning observed activity to individual components of combinatorial libraries, screened in HTS bioassays

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of combinatorial library synthesis: 2001.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Scalable methods for the construction and analysis of virtual combinatorial libraries

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of combinatorial library synthesis: 2000.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

14 September 2017

Combinatorial networks

1 reference

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Use of Markush structure analysis techniques for descriptor generation and clustering of large combinatorial libraries.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of combinatorial library synthesis: 1999.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

The in silico world of virtual libraries

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992-1997.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

UPS on Weinreb resin: a facile solid-phase route to aldehyde and ketone derivatives of "unnatural" amino acids and peptides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Comprehensive survey of combinatorial library synthesis: 1998.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651689

Solid phase organic synthesis (SPOS): A novel route to diketopiperazines and diketomorpholines

14 September 2017

1 reference

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"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity

14 September 2017

1 reference

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From molecular diversity to catalysis: lessons from the immune system

14 September 2017

1 reference

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New non-profit organization will support research to combat neglected diseases.

14 September 2017

1 reference

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Buying a cure: what business know-how can do for disease

27 June 2018

1 reference

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Changing requirements of purification as drug discovery programs evolve from hit discovery

3 September 2018

1 reference

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Solid-phase synthesis of multiple classes of peptidomimetics from versatile resin-bound aldehyde intermediates.

3 September 2018

1 reference

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A computer-aided drug discovery system for chemistry teaching

3 September 2018

1 reference

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Developing drugs for neglected diseases

3 September 2018

1 reference

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Oxymoron no more: the potential of nonprofit drug companies to deliver on the promise of medicines for the developing world

3 September 2018

1 reference

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Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening

3 September 2018

1 reference

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Combating bioterrorism with personal computers

3 September 2018

1 reference

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The world's most neglected diseases

3 September 2018

1 reference

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Virtual screening using grid computing: the screensaver project.

3 September 2018

1 reference

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A solid-phase synthetic route to unnatural amino acids with diverse side-chain substitutions

3 September 2018

1 reference

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3 September 2018

1 reference

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Health Innovation Networks to Help Developing Countries Address Neglected Diseases

3 September 2018

1 reference

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Open-source science to enable drug discovery

20 October 2018

1 reference

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The path to new medicines

4 December 2018

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

Analytical and biological evaluation of high throughput screen actives using evaporative light scattering, chemiluminescent nitrogen detection, and accurate mass LC-MS-MS

1 reference

12 December 2020

How many leads from HTS?

1 reference

12 December 2020

Intellectual property. Commons-based strategies and the problems of patents

1 reference

12 December 2020

Molecular biology. Industrial-style screening meets academic biology

1 reference

12 December 2020

Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics

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12 December 2020

How many leads from HTS? - Comment

1 reference

12 December 2020

Not-for-profit drugs--no longer an oxymoron?

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12 December 2020

Solid phase synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1021/CC800183M

1 reference

18 August 2017

1 reference

PMC publication ID

2651689

18 August 2017

PubMed publication ID

19105724

1 reference

PMC publication ID

2651689