Roles of unphosphorylated STATs in signaling (Q37118445)

18 August 2017

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title

Roles of unphosphorylated STATs in signaling (English)

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18 August 2017

Jinbo Yang

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18 August 2017

George R Stark

series ordinal

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18 August 2017

publication date

1 April 2008

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18 August 2017

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

443-451

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The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STATs and Gene Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Stats: transcriptional control and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Different requirements for signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 in the regulation of low molecular mass polypeptide 2 and transporter associated with antigen processing 1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Jaks and Stats in signaling by the cytokine receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

How cells respond to interferons

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Type I IFN modulates innate and specific antiviral immunity.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Interferons, immunity and cancer immunoediting

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Distinct requirements for IFNs and STAT1 in NK cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

The roles of IFN gamma in protection against tumor development and cancer immunoediting

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT1 acts as a tumor promoter for leukemia development

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT3 is required for the gp130-mediated full activation of the c-myc gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Independent and cooperative activation of chromosomal c-fos promoter by STAT3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

The role of STATs in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT3 as a downstream mediator of Trk signaling and functions

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Structure of the amino-terminal protein interaction domain of STAT-4

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Specific Inhibition of Stat3 Signal Transduction by PIAS3

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT3 acts as a co-activator of glucocorticoid receptor signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

An interleukin-4-induced transcription factor: IL-4 Stat

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

STAT family of transcription factors in cytokine-mediated biological responses

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Alternative activation of STAT1 and STAT3 in response to interferon-gamma

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

The Jak/STAT pathway in model organisms: emerging roles in cell movement

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Stat3 Controls Cell Movements during Zebrafish Gastrulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2008.41

7 January 2021

Activation of STAT proteins and growth control

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

7 January 2021

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

7 January 2021

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.41

7 January 2021

Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

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https://api.crossref.org/works/10.1038%2FCR.2008.41

7 January 2021

Identifiers

DOI

10.1038/CR.2008.41

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18 August 2017

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