Application of prodrugs to inflammatory diseases of the gut. (Q37096512)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18305431%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

review article

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title

Application of prodrugs to inflammatory diseases of the gut (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18305431%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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Helieh S Oz

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3 January 2020

Jeffrey L Ebersole

series ordinal

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3 January 2020

language of work or name

English

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publication date

27 February 2008

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3 January 2020

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3 January 2020

volume

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3 January 2020

issue

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3 January 2020

page(s)

452-474

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Creative Commons Attribution 4.0 International

3 January 2020

start time

27 February 2008

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Assessment of orocaecal transit time in different localization of Crohn's disease and its possible influence on clinical response to therapy

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Pharmacokinetic considerations in the treatment of inflammatory bowel disease

21 January 2018

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Estimating drug solubility in the gastrointestinal tract

21 January 2018

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Prodrugs. Do they have advantages in clinical practice?

21 January 2018

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Lessons learned from marketed and investigational prodrugs

21 January 2018

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Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates

21 January 2018

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Synthesis of a novel prodrug of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid for colon delivery

21 January 2018

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Inflammatory Bowel Disease

21 January 2018

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Mortality by medication use among patients with inflammatory bowel disease, 1996-2003.

21 January 2018

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IL-10 and its related cytokines for treatment of inflammatory bowel disease

21 January 2018

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Immune dysfunction in inflammatory bowel disease

21 January 2018

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General principles and pharmacology of biologics in inflammatory bowel disease.

21 January 2018

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Treatment of inflammatory bowel disease: a review of medical therapy

21 January 2018

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Enteric Microflora in IBD: Pathogens or Commensals?

21 January 2018

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Measles virus and Crohn's disease: a critical appraisal of the current literature

21 January 2018

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 January 2018

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Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease

21 January 2018

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The indigenous gastrointestinal microflora

21 January 2018

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Probiotics in inflammatory bowel disease--therapeutic rationale and role

21 January 2018

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Anti-TNF-α Antibody Normalizes Serum Leptin in IL-2 Deficient Mice

21 January 2018

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

21 January 2018

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 January 2018

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

21 January 2018

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Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

21 January 2018

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Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites

21 January 2018

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21 January 2018

Oxidative Decay of DNA

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Oxygen radicals in ulcerative colitis

21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Comparative tolerability of treatments for inflammatory bowel disease

21 January 2018

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PPARgamma as a new therapeutic target in inflammatory bowel diseases

21 January 2018

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Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis

21 January 2018

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Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion

21 January 2018

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Omeprazole for gastroesophageal reflux disease in the first 2 years of life: a dose-finding study with dual-channel pH monitoring

21 January 2018

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Omeprazole: pharmacology, pharmacokinetics and interactions

21 January 2018

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Resistant starch and “the butyrate revolution”

21 January 2018

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Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation.

21 January 2018

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Inborn errors of mitochondrial fatty acid oxidation

21 January 2018

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Fatty acid transport and mitochondrial oxidation disorders

21 January 2018

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Fatty acid oxidation disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)

21 January 2018

1 reference

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Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasone

21 January 2018

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Provocative effects of the immunosuppressants rapamycin, tacrolimus, and dexamethasone on pneumonitis in contrast to the anti- pneumonitis effects of mycophenolate mofetil

21 January 2018

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Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients

21 January 2018

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Mycophenolate mofetil reduces tissue damage and inflammation in an experimental model of colitis in rats

21 January 2018

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Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease

21 January 2018

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Cyclosporine, tacrolimus, and mycophenolate mofetil in the treatment of inflammatory bowel disease

21 January 2018

1 reference

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Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation

21 January 2018

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Glutathione is required for intestinal function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

The physiological consequences of glutathione variations.

21 January 2018

1 reference

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Antioxidants as novel therapy in a murine model of colitis

21 January 2018

1 reference

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Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease

21 January 2018

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Diverse antioxidants protect against acetaminophen hepatotoxicity

21 January 2018

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Induction of enlarged intestinal lymphoid aggregates during acute glutathione depletion in a murine model

21 January 2018

1 reference

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Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Status of glutathione and other thiols and disulfides in human plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Replenishment of glutathione levels improves mucosal function in experimental acute colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Experimental colitis in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Hepatoprotection by L‐cysteine‐glutathione mixed disulfide, a sulfhydryl‐modified prodrug of glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Glutathione-enhancing agents protect against steatohepatitis in a dietary model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

S-adenosylmethionine synthesis: molecular mechanisms and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Methionine derivatives diminish sulphide damage to colonocytes--implications for ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Thiol methyltransferase activity in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Methionine deficiency and hepatic injury in a dietary steatohepatitis model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Chemical Aspects of Selective Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020452

Mycophenolic acid: measurement and relationship to pharmacologic effects.

21 January 2018

1 reference

12 December 2020

Life span profiles of glutathione and acetaminophen detoxification

1 reference

12 December 2020

Targeted prodrug design to optimize drug delivery

1 reference

12 December 2020

A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis

1 reference

12 December 2020

Transmethylation, transsulfuration, and aminopropylation reactions of S-adenosyl-L-methionine in vivo

1 reference

12 December 2020

Metabolism of foreign compounds by gastrointestinal microorganisms

1 reference

12 December 2020

Acetylated, Propionylated or Butyrylated Starches Raise Large Bowel Short-Chain Fatty Acids Preferentially When Fed to Rats

1 reference

12 December 2020

Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model

1 reference

12 December 2020

2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

1 reference

12 December 2020

Polyamine metabolism in colonic mucosa from patients with ulcerative colitis

1 reference

12 December 2020

Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study

1 reference

12 December 2020

Accumulation of cystine from glutathione-cysteine mixed disulfide in cystinotic fibroblasts; blockade by an inhibitor of γ-glutamyl transpeptidase

1 reference

12 December 2020

Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself.

1 reference

12 December 2020

Budesonide for ulcerative colitis.

1 reference

12 December 2020

Chronic inflammation alters protein metabolism in several organs of adult rats

1 reference

12 December 2020

Mycophenolate mofetil-induced colonic ulceration in renal transplant recipients

1 reference

12 December 2020

Glutathione deficiency increases organ dysfunction after hemorrhagic shock

1 reference

12 December 2020

Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis

1 reference

12 December 2020

Current applications of polysaccharides in colon targeting

1 reference

12 December 2020

Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA

1 reference

12 December 2020

Stimulation of colonic mucosal growth associated with oxidized redox status in rats

1 reference

12 December 2020

Therapy of inflammatory bowel disease.

1 reference

12 December 2020

Decreased food intake rather than zinc deficiency is associated with changes in plasma leptin, metabolic rate, and activity levels in zinc deficient rats( small star, filled)

1 reference

12 December 2020

Oxygen-derived free radical generating capacity of polymorphonuclear cells in patients with ulcerative colitis

1 reference

12 December 2020

Approaches and opportunities in colon-specific drug delivery.

1 reference

12 December 2020

Mycophenolate mofetil

1 reference

12 December 2020

Colonic drug targeting

1 reference

12 December 2020

Rat enterocyte injury by oxygen-dependent processes

1 reference

12 December 2020

The reduction of the L-cysteine-glutathione mixed disulfide in rat liver. involvement of an enzyme catalyzing thiol-disulfide interchange

1 reference

12 December 2020

Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides

1 reference

12 December 2020

Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide

1 reference

12 December 2020

Hypocholesterolaemic effects of dietary propionate: studies in whole animals and perfused rat liver

1 reference

12 December 2020

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

1 reference

12 December 2020

Energy contributions of volatile fatty acids from the gastrointestinal tract in various species

1 reference

12 December 2020

Role of oxygen-derived free radicals in digestive tract diseases.

1 reference

12 December 2020

Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis

1 reference

12 December 2020

Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis

1 reference

12 December 2020

Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities

1 reference

12 December 2020

An HPLC radiotracer method for assessing the ability of L-Cysteine prodrugs to maintain glutathione levels in the cultured rat lens

1 reference

12 December 2020

IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid

1 reference

12 December 2020

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice

1 reference

12 December 2020

Increased respiratory burst of leukocytes in inflammatory bowel diseases--the analysis of free radical generation by using chemiluminescence probe

1 reference

12 December 2020

Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease

1 reference

12 December 2020

Thiolmethyltransferase activity in the human colonic mucosa: Implications for ulcerative colitis

1 reference

12 December 2020

Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis

1 reference

12 December 2020

Treatment of steroid refractory inflammatory bowel disease (IBD) with mycophenolate mofetil (MMF)

1 reference

12 December 2020

Is mycophenolate mofetil an effective alternative in azathioprine-intolerant patients with chronic active Crohn's disease?

1 reference

12 December 2020

10.3390/MOLECULES13020452

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18305431%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18305431%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18305431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18305431%20AND%20SRC:MED&resulttype=core&format=json