The role of metals in modulating metalloprotease activity in the AD brain. (Q37083267)

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2 January 2020

review article

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title

The role of metals in modulating metalloprotease activity in the AD brain (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18270696%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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2 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18270696%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Gulay Filiz

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2 January 2020

Katherine A Price

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2 January 2020

Aphrodite Caragounis

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2 January 2020

Tai Du

series ordinal

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2 January 2020

publication date

13 February 2008

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European Biophysics Journal

2 January 2020

published in

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2 January 2020

volume

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2 January 2020

issue

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2 January 2020

page(s)

315-321

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Tissue inhibitors of metalloproteinases: evolution, structure and function

2 January 2020

cites work

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Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

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Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

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Protein modules and signalling networks

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

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Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

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A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

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Epidermal growth factor selectively enhances NMDA receptor-mediated increase of intracellular Ca2+ concentration in rat hippocampal neurons

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

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Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas

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Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium.

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Effect of oxidation of beta-amyloid precursor protein on its beta-secretase cleavage. A model study with synthetic peptides and candidate beta-secretases.

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Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

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Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.

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Copper, iron and zinc in Alzheimer's disease senile plaques

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Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels

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Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

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12 December 2020

The metallobiology of Alzheimer's disease

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

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12 December 2020

Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes

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12 December 2020

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

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12 December 2020

Metal homeostasis in Alzheimer's disease

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12 December 2020

Regulation of neurogenesis by growth factors and neurotransmitters

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway

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SH2/SH3 signaling proteins

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Transgenic and knock-out mice for deciphering the roles of EGFR ligands

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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In vivo reduction of amyloid-beta by a mutant copper transporter

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Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

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12 December 2020

Differential production of metalloproteinases after instilling various urban air particle samples to rat lung

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12 December 2020

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

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12 December 2020

Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation

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12 December 2020

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

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12 December 2020

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

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12 December 2020

Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes

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12 December 2020

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

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12 December 2020

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

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12 December 2020

Matrix metalloproteinases and diseases of the CNS.

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12 December 2020

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

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12 December 2020

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

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12 December 2020

Effect of copper deficiency and cis-diamminedichloroplatinum (II) treatment on the activities of renal microvillar enzymes in rats

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12 December 2020

Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis

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12 December 2020

Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor

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12 December 2020

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

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12 December 2020

Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease

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12 December 2020

Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.

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12 December 2020