Epac: effectors and biological functions (Q37051159)

17 August 2017

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title

Epac: effectors and biological functions (English)

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17 August 2017

Sara S Roscioni

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17 August 2017

Carolina R S Elzinga

series ordinal

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17 August 2017

Martina Schmidt

series ordinal

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17 August 2017

publication date

5 January 2008

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Naunyn-Schmiedeberg's Archives of Pharmacology

17 August 2017

published in

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17 August 2017

volume

377

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17 August 2017

issue

4-6

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17 August 2017

page(s)

345-357

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Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

17 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00210-007-0246-7

Ras GTPases: integrins' friends or foes?

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00210-007-0246-7

Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00210-007-0246-7

Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).

21 January 2018

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12 December 2020

Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts

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12 December 2020

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

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12 December 2020

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

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12 December 2020

Integrins regulate Rac targeting by internalization of membrane domains

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12 December 2020

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

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12 December 2020

EPAC regulation of cardiac EC coupling

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12 December 2020

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

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12 December 2020

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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12 December 2020

Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation

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12 December 2020

Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties

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12 December 2020

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

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12 December 2020

Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis

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12 December 2020

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

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12 December 2020

Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells

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12 December 2020

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

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12 December 2020

Phospholipase C(epsilon): a novel Ras effector

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12 December 2020

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

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12 December 2020

GAP control: regulating the regulators of small GTPases

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12 December 2020

Rap1: a key regulator in cell-cell junction formation

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12 December 2020

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

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12 December 2020

Analysis of R-Ras signalling pathways.

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12 December 2020

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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12 December 2020

Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation

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12 December 2020

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

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12 December 2020

Signaling interplay in Ras superfamily function

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12 December 2020

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

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12 December 2020

How do microtubules guide migrating cells?

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12 December 2020

Thyrotropin activates mitogen-activated protein kinase pathway in FRTL-5 by a cAMP-dependent protein kinase A-independent mechanism

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12 December 2020

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

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12 December 2020

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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12 December 2020

Rap1 signalling: adhering to new models

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12 December 2020

AKAP signalling complexes: focal points in space and time

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12 December 2020

Inhibition of phospholipase C-epsilon by Gi-coupled receptors

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12 December 2020

Linking Rap to cell adhesion

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12 December 2020

Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells

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12 December 2020

Matrix metalloproteinases and the regulation of tissue remodelling

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12 December 2020

The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages

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12 December 2020

Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase

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12 December 2020

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

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12 December 2020

Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

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12 December 2020

Recent advances in the protein kinase B signaling pathway

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12 December 2020

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

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12 December 2020

Ras signaling from plasma membrane and endomembrane microdomains

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12 December 2020

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

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12 December 2020

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation

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12 December 2020

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

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12 December 2020

cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.

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12 December 2020

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

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12 December 2020

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

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12 December 2020

The Ras superfamily at a glance

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12 December 2020

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

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12 December 2020

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

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12 December 2020

Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4

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12 December 2020

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes

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12 December 2020

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

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12 December 2020

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

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12 December 2020

Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early development

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12 December 2020

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

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12 December 2020

Epac-mediated Ca(2+) mobilization and exocytosis in inner medullary collecting duct

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12 December 2020

MMPs, cadherins, and cell proliferation

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12 December 2020

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

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12 December 2020

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

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12 December 2020

Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.

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12 December 2020

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

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12 December 2020

Phosphoinositides and signal transduction

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12 December 2020

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells

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12 December 2020

Epac and the cardiovascular system

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12 December 2020

A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation

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12 December 2020

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

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12 December 2020

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

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12 December 2020

GEFs and GAPs: critical elements in the control of small G proteins

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12 December 2020

The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas

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12 December 2020

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

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12 December 2020

Cyclic AMP-dependent, protein kinase A-independent activation of extracellular signal-regulated kinase 1/2 following adenosine receptor stimulation in human umbilical vein endothelial cells: role of exchange protein activated by cAMP 1 (Epac1)

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12 December 2020

Calcium signalling: dynamics, homeostasis and remodelling

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12 December 2020

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

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12 December 2020

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members

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12 December 2020

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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12 December 2020

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

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12 December 2020

Mechanism of the spatio-temporal regulation of Ras and Rap1.

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12 December 2020

A family of cAMP-binding proteins that directly activate Rap1

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12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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12 December 2020

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

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12 December 2020

Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline

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12 December 2020

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase

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12 December 2020

Intermediate filaments mediate cytoskeletal crosstalk

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12 December 2020

The effects of PACAP on neural cell proliferation

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12 December 2020

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

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12 December 2020

cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells

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12 December 2020

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

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12 December 2020

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

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12 December 2020

Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors

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12 December 2020

Glucagon activates Ca2+ and Cl- channels in rat hepatocytes

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12 December 2020

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

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12 December 2020

PIP2 and PIP as determinants for ATP inhibition of KATP channels

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12 December 2020

AKAP signaling complexes: getting to the heart of the matter

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12 December 2020

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

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12 December 2020

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

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12 December 2020

Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger

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12 December 2020

Novel single chain cAMP sensors for receptor-induced signal propagation.

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12 December 2020

Regulation of mTOR by phosphatidic acid?

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12 December 2020

Epac proteins: multi-purpose cAMP targets

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12 December 2020

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

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12 December 2020

Phospholipase D-structure, regulation and function

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12 December 2020

The role of Rap1 in integrin-mediated cell adhesion

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12 December 2020

Cyclic nucleotide research -- still expanding after half a century

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12 December 2020

Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B

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12 December 2020

Microtubule-associated proteins (MAPs) regulate cAMP signalling through exchange protein directly activated by cAMP (EPAC).

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12 December 2020

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane

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12 December 2020

Does Rap1 deserve a bad Rap?

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12 December 2020

Integration of calcium and Ras signalling.

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12 December 2020

Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

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12 December 2020

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

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12 December 2020

Phospholipase C epsilon: linking second messengers and small GTPases

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12 December 2020

Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants

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12 December 2020

AKAP signaling complexes at the cytoskeleton

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12 December 2020

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

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12 December 2020

Small GTP-binding proteins

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon

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12 December 2020

MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.

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12 December 2020

Exocytosis: proteins and perturbations

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12 December 2020

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

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12 December 2020

Rho GTPases: biochemistry and biology

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12 December 2020

R-Ras alters Ca2+ homeostasis by increasing the Ca2+ leak across the endoplasmic reticular membrane.

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12 December 2020

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

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12 December 2020

Cell physiology of cAMP sensor Epac

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12 December 2020

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

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12 December 2020

Rap1 regulates E-cadherin-mediated cell-cell adhesion

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12 December 2020

GAPs in growth factor signalling

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12 December 2020

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

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12 December 2020

Epac: a new cAMP target and new avenues in cAMP research

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12 December 2020

Coupling of neuronal 5‐HT7 receptors to activation of extracellular‐regulated kinase through a protein kinase A‐independent pathway that can utilize Epac

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12 December 2020

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

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12 December 2020

Inhibition of phospholipase C-ε by Gi-coupled receptors

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12 December 2020

10.1007/S00210-007-0246-7

Identifiers

DOI

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17 August 2017

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