IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death (Q37040433)

17 August 2017

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death (English)

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Małgorzata Czystowska-Kuźmicz

17 August 2017

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object named as

M Czystowska

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17 August 2017

J Han

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17 August 2017

M J Szczepanski

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17 August 2017

M Szajnik

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17 August 2017

K Quadrini

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17 August 2017

H Brandwein

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17 August 2017

J W Hadden

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17 August 2017

K Signorelli

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17 August 2017

T L Whiteside

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17 August 2017

30 January 2009

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Cell Death & Differentiation

17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

708-718

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Tumour-released exosomes and their implications in cancer immunity.

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Regulation of T cell homeostasis by JAKs and STATs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Tumor-released microvesicles as vehicles of immunosuppression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

cFLIP regulation of lymphocyte activation and development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

The activation of Akt/PKB signaling pathway and cell survival.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Cytokines in cancer immunity and immunotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

The Fas signaling pathway: more than a paradigm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

The Fas counterattack: cancer as a site of immune privilege

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

IRX-2 and thymosin alpha1 (Zadaxin) increase T lymphocytes in T lymphocytopenic mice and humans.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Tumour-derived exosomes or microvesicles: another mechanism of tumour escape from the host immune system?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

A trial of IRX-2 in patients with squamous cell carcinomas of the head and neck

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

A pilot study of perilymphatic leukocyte cytokine mixture (IRX-2) as neoadjuvant treatment for early stage cervical carcinoma

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721331

Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes

4 September 2018

1 reference

12 December 2020

FasL:Fas ratio--a prognostic factor in breast carcinomas

1 reference

12 December 2020

Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial

1 reference

12 December 2020

A comparative study of Fas and Fas-ligand expression during melanoma progression

1 reference

12 December 2020

Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance

1 reference

12 December 2020

Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma

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12 December 2020

Lymph node histology in head and neck cancer: impact of immunotherapy with IRX-2

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12 December 2020

Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer

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12 December 2020

IRX-2, a novel in vivo immunotherapeutic, induces maturation and activation of human dendritic cells in vitro

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12 December 2020

Identifiers

DOI

10.1038/CDD.2008.197

1 reference

17 August 2017

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17 August 2017

PubMed publication ID

19180118

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