Complement driven by conformational changes (Q37026644)

17 August 2017

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title

Complement driven by conformational changes (English)

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17 August 2017

Piet Gros

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17 August 2017

Fin J Milder

series ordinal

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17 August 2017

Bert J C Janssen

series ordinal

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17 August 2017

publication date

1 January 2008

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Nature Reviews Immunology

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

48-58

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Complement. First of two parts

17 August 2017

cites work

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Genomic view of the evolution of the complement system.

31 March 2020

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Structure and flexibility of the multiple domain proteins that regulate complement activation

31 March 2020

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Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics

31 March 2020

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Molecular organization and function of the complement system

31 March 2020

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Mannose-binding lectin: the pluripotent molecule of the innate immune system

31 March 2020

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Complement. Second of two parts

31 March 2020

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Lectin complement system and pattern recognition

31 March 2020

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The multifunctional role of C3, the third component of complement

31 March 2020

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Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

31 March 2020

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Structures of complement component C3 provide insights into the function and evolution of immunity

31 March 2020

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The structure of bovine complement component 3 reveals the basis for thioester function

31 March 2020

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Structure of C3b reveals conformational changes that underlie complement activity

31 March 2020

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Structure of C3b in complex with CRIg gives insights into regulation of complement activation

31 March 2020

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Structural transitions of complement component C3 and its activation products

31 March 2020

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Factor B structure provides insights into activation of the central protease of the complement system

31 March 2020

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Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase

31 March 2020

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Structure of complement component C2A: implications for convertase formation and substrate binding

31 March 2020

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The Crystal Structure of C2a, the Catalytic Fragment of Classical Pathway C3 and C5 Convertase of Human Complement

31 March 2020

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Thioester-containing proteins and insect immunity

31 March 2020

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Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome?

31 March 2020

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Crystal structure analysis and molecular model of human C3a anaphylatoxin

31 March 2020

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X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2

31 March 2020

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The structure of complement C3b provides insights into complement activation and regulation

31 March 2020

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Crystallography: crystallographic evidence for deviating C3b structure

31 March 2020

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Human complement component C3: cDNA coding sequence and derived primary structure

31 March 2020

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Structural basis for conserved complement factor-like function in the antimalarial protein TEP1.

31 March 2020

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Evidence for presence of an internal thiolester bond in third component of human complement.

31 March 2020

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Third component of human complement: Localization of the internal thiolester bond

31 March 2020

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Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

31 March 2020

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Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

31 March 2020

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The covalent-binding reaction of complement component C3

31 March 2020

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Complement inactivation by recombinant human C3 derivatives.

31 March 2020

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Engineering of human complement component C3 for catalytic inhibition of complement

31 March 2020

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The role of properdin in the assembly of the alternative pathway C3 convertases of complement

31 March 2020

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Complement C3: A molecular mosaic of binding sites

31 March 2020

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Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B

31 March 2020

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Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35).

31 March 2020

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Structure and function of complement C5 convertase enzymes

31 March 2020

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The membrane attack complex of complement

31 March 2020

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The complement system in regulation of adaptive immunity

31 March 2020

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CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens

31 March 2020

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Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study

31 March 2020

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Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

31 March 2020

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The human complement system: assembly of the classical pathway C3 convertase

31 March 2020

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Structural basis of collagen recognition by integrin alpha2beta1

31 March 2020

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

31 March 2020

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

31 March 2020

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Crystal Structure of the I Domain from Integrin α2β1

31 March 2020

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Analysis of the Short Consensus Repeats of Human Complement Factor B by Site-directed Mutagenesis

31 March 2020

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A reexamination of the role of magnesium in the human alternative pathway of complement

31 March 2020

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

31 March 2020

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New structural motifs on the chymotrypsin fold and their potential roles in complement factor B

31 March 2020

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Complement factor D, a novel serine protease

31 March 2020

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Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity

31 March 2020

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Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry

31 March 2020

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

31 March 2020

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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1

31 March 2020

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Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor

31 March 2020

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The supportive role of complement in HIV pathogenesis

31 March 2020

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Opportunities for new therapies based on the natural regulators of complement activation

31 March 2020

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Bacterial complement evasion.

31 March 2020

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Virus complement evasion strategies

31 March 2020

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Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins

31 March 2020

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Regulation of complement activity by vaccinia virus complement-control protein

31 March 2020

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Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates

31 March 2020

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A structural basis for complement inhibition by Staphylococcus aureus

31 March 2020

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Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases

31 March 2020

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Proteases of the complement system

31 March 2020

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The human mannose-binding protein functions as an opsonin

31 March 2020

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Cleavage of the third component of complement (C3) by mannose-binding protein-associated serine protease (MASP) with subsequent complement activation

31 March 2020

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A second serine protease associated with mannan-binding lectin that activates complement

31 March 2020

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Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2231

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Dimensions Publication ID

17 August 2017

1011880882

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