Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. (Q36983065)

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scientific article published on November 2008

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English	Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.	scientific article published on November 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

object named as

Joan Seoane

9

0 references

object named as

Violeta Serra

4

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object named as

René Bernards

10

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Roderick L Beijersbergen

object named as

Roderick L Beijersbergen

7

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6

object named as

Wouter Nijkamp

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Pieter J A Eichhorn

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Magüi Gili

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Maurizio Scaltriti

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Marta Guzman

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Vanesa Valero

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

José Baselga

11

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

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publication date

1 November 2008

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Europe PubMed Central

PMC publication ID

17 August 2017

Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

68

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Europe PubMed Central

PMC publication ID

17 August 2017

22

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Europe PubMed Central

PMC publication ID

17 August 2017

9221-9230

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Europe PubMed Central

PMC publication ID

17 August 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

1 reference

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29 September 2017

Targeting phosphoinositide 3-kinase: moving towards therapy

1 reference

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

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Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines

1 reference

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

1 reference

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Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

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Cancer-specific mutations in PIK3CA are oncogenic in vivo

1 reference

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29 September 2017

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

1 reference

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29 September 2017

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

1 reference

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29 September 2017

Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

1 reference

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29 September 2017

Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

1 reference

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

1 reference

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

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The TOR pathway: a target for cancer therapy

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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1 reference

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12 December 2020

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Identifiers

10.1158/0008-5472.CAN-08-1740

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

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