Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures (Q36987092)

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scientific article published on March 2008

Language	Label	Description	Also known as
English	Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures	scientific article published on March 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

Europe PubMed Central

Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

author name string

Jane C Caldwell

1

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Nagalakshmi Keshava

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Marina V Evans

3

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

publication date

1 March 2008

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Europe PubMed Central

PubMed publication ID

17 August 2017

Environmental and Molecular Mutagenesis

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Europe PubMed Central

PubMed publication ID

17 August 2017

49

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Europe PubMed Central

PubMed publication ID

17 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

142-154

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate

1 reference

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21 January 2018

Human variability and susceptibility to trichloroethylene

1 reference

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21 January 2018

Exposure assessment of trichloroethylene

1 reference

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ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice

1 reference

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Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

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Alcohol metabolism: role in toxicity and carcinogenesis

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Mediation by nitric oxide of the stimulatory effects of ethanol on blood flow

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Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

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Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms

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Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate

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Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene

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Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice

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Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis

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A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid

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Key scientific issues in the health risk assessment of trichloroethylene

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Issues in the pharmacokinetics of trichloroethylene and its metabolites

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Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth.

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Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration

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Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: dose-response determination and modes of action

1 reference

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7 January 2021

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Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.

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In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane

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Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital

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Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics of components of complex chemical mixtures

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Visualization-based analysis for a mixed-inhibition binary PBPK model: determination of inhibition mechanism

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Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway

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Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice

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7 January 2021

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Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity

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7 January 2021

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PPARalpha agonist-induced rodent tumors: modes of action and human relevance

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In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.

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Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice

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Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-kappaB and AP-1 or with expression of tumor necrosis factor alpha.

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Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice

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Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice

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Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice

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Trichloroethylene cancer epidemiology: a consideration of select issues

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Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA)

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Pretreatment with drinking water solutions containing trichloroethylene or chloroform enhances the hepatotoxicity of carbon tetrachloride in Fischer 344 rats

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Time course of hepatic injury and recovery following coadministration of carbon tetrachloride and trichloroethylene in Fischer-344 rats

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Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate

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Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver

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Trichloroethylene inhibits aldehyde dehydrogenase only for aliphatic aldehydes of short chains in rats

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Identifiers

10.1002/EM.20350

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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