Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1. (Q36977342)

17 August 2017

Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1. (English)

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17 August 2017

Leena P Desai

1 reference

17 August 2017

Kenneth E Chapman

series ordinal

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17 August 2017

Christopher M Waters

series ordinal

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17 August 2017

19 September 2008

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American Journal of Physiology - Lung Cellular and Molecular Physiology

17 August 2017

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17 August 2017

295

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17 August 2017

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17 August 2017

L958-65

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Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems

17 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Low-tidal-volume ventilation in the acute respiratory distress syndrome

29 September 2017

1 reference

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Airway strain during mechanical ventilation in an intact animal model

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion

29 September 2017

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MEK/ERK regulates adherens junctions and migration through Rac1

29 September 2017

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Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells

29 September 2017

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In vivo dynamics of Rac-membrane interactions

29 September 2017

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Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration

29 September 2017

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Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management

29 September 2017

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Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells

29 September 2017

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Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation

29 September 2017

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How to ventilate patients with acute lung injury and acute respiratory distress syndrome.

29 September 2017

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New insights into the pathology of acute respiratory failure

29 September 2017

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Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

29 September 2017

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Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression

29 September 2017

1 reference

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Effects of cell tension on the small GTPase Rac

29 September 2017

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Dbl family guanine nucleotide exchange factors

29 September 2017

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Deformation-induced lipid trafficking in alveolar epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases

29 September 2017

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Signaling networks linking integrins and rho family GTPases.

29 September 2017

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The acute respiratory distress syndrome

29 September 2017

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Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganisation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Activation of Rac and Cdc42 by integrins mediates cell spreading

29 September 2017

1 reference

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Rho GTPases and the actin cytoskeleton

29 September 2017

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Cell locomotion and focal adhesions are regulated by substrate flexibility

29 September 2017

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Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

29 September 2017

1 reference

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Rho GTPases and signaling networks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

The Dbl family of oncogenes

29 September 2017

1 reference

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A role for Rac in Tiam1-induced membrane ruffling and invasion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Adverse effects of large tidal volume and low PEEP in canine acid aspiration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Isolation and culture of alveolar type II cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration

27 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

The Rho exchange factor Net1 is regulated by nuclear sequestration

27 June 2018

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Ventilator-induced lung injury: lessons from experimental studies

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Rac is a dominant regulator of cadherin-directed actin assembly that is activated by adhesive ligation independently of Tiam1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Regulation of rat alveolar type 2 cell proliferation in vitro involves type II cAMP-dependent protein kinase.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Ventilator-induced cell wounding and repair in the intact lung

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Repeated derecruitments accentuate lung injury during mechanical ventilation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms

4 September 2018

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Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung

4 September 2018

1 reference

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Role of stretch on tight junction structure in alveolar epithelial cells

4 September 2018

1 reference

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Interleukin-1beta augments in vitro alveolar epithelial repair

4 September 2018

1 reference

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Tidal ventilation at low airway pressures can augment lung injury.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2584892

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

4 September 2018

1 reference

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Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model

4 September 2018

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Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells

4 September 2018

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12 December 2020

Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs

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12 December 2020

Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure

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12 December 2020

Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method

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12 December 2020

16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway

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12 December 2020

Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation

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12 December 2020

Surfactant dysfunction makes lungs vulnerable to repetitive collapse and reexpansion

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12 December 2020

Mechanical strain inhibits repair of airway epithelium in vitro

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12 December 2020

Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude

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12 December 2020

Alveolar expansion imaged by optical sectioning microscopy

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12 December 2020

10.1152/AJPLUNG.90218.2008

Identifiers

DOI

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

18805958

1 reference